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Dietary D ‐psicose, a C‐3 epimer of D ‐fructose, suppresses the activity of hepatic lipogenic enzymes in rats

2001; Wiley; Volume: 10; Issue: 3 Linguagem: Inglês

10.1046/j.1440-6047.2001.00246.x

1440-6047

Tatsuhiro Matsuo, Yoshitake Baba, Mineo HASHIGUCHI, Kei Takeshita, Ken Izumori, Hiroo Suzuki,

Alcohol Consumption and Health Effects

D‐Psicose ( D ‐ ribo ‐2‐hexulose), a C‐3 epimer of D ‐fructose, is present in small quantities in commercial carbohydrate complexes or agricultural products. Wistar male rats were fed experimental diets which consisted of 5% D ‐psicose, cellulose, D ‐fructose or D ‐glucose for 28 days. Abdominal adipose tissue weight was significantly lower ( P < 0.05) in rats fed the D ‐psicose diet than in rats fed a D ‐fructose and D ‐glucose diets, even though the four dietary groups were offered the same amount throughout the experimental period. Fatty acid synthase and glucose 6‐phosphate dehydrogenase activities in the liver were significantly lower ( P < 0.05) in rats fed the D ‐psicose diet than in rats fed the D ‐fructose and D ‐glucose diets. However, lipoprotein lipase activities in the heart, soleus muscle and perirenal adipose tissue were the same. These results suggest that a supplement of D ‐psicose in the diet suppresses hepatic lipogenic enzyme activities. The lower abdominal fat accumulation in rats fed a D ‐psicose diet might result from lower lipogenesis in the liver.