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Hypoglycemia in Children Taking Propranolol for the Treatment of Infantile Hemangioma

2010; American Medical Association; Volume: 146; Issue: 7 Linguagem: Inglês

10.1001/archdermatol.2010.158

1538-3652

Kristen E. Holland, Ilona J. Frieden, Peter C. Frommelt, Anthony J. Mancini, David T. Wyatt, Beth A. Drolet,

Head and Neck Surgical Oncology

Background Propranolol hydrochloride has been prescribed for decades in the pediatric population for a variety of disorders, but its effectiveness in the treatment of infantile hemangiomas (IHs) was only recently discovered. Since then, the use of propranolol for IHs has exploded because it is viewed as a safer alternative to traditional therapy. Observations We report the cases of 3 patients who developed symptomatic hypoglycemia during treatment with propranolol for their IHs and review the literature to identify other reports of propranolol-associated hypoglycemia in children to highlight this rare adverse effect. Conclusions Although propranolol has a long history of safe and effective use in infants and children, understanding and recognition of deleterious adverse effects is critical for physicians and caregivers. This is especially important when new medical indications evolve as physicians who may not be as familiar with propranolol and its adverse effects begin to recommend it as therapy.