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Pharmacological and therapeutic effects of A3 adenosine receptor agonists

2011; Elsevier BV; Volume: 17; Issue: 7-8 Linguagem: Inglês

10.1016/j.drudis.2011.10.007

1878-5832

Pnina Fishman, Sara Bar‐Yehuda, Bruce T. Liang, Kenneth A. Jacobson,

RNA Interference and Gene Delivery

The A3 adenosine receptor (A3AR) coupled to Gi (inhibitory regulative guanine nucleotide-binding protein) mediates anti-inflammatory, anticancer and anti-ischemic protective effects. The receptor is overexpressed in inflammatory and cancer cells, while low expression is found in normal cells, rendering the A3AR as a potential therapeutic target. Highly selective A3AR agonists have been synthesized and molecular recognition in the binding site has been characterized. In this article, we summarize preclinical and clinical human studies that demonstrate that A3AR agonists induce specific anti-inflammatory and anticancer effects through a molecular mechanism that entails modulation of the Wnt and the NF-κB signal transduction pathways. At present, A3AR agonists are being developed for the treatment of inflammatory diseases, including rheumatoid arthritis (RA) and psoriasis; ophthalmic diseases such as dry eye syndrome and glaucoma; liver diseases such as hepatocellular carcinoma and hepatitis.