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Assessing advantages of sequential boron neutron capture therapy (BNCT) in an oral cancer model with normalized blood vessels

2014; Taylor & Francis; Volume: 54; Issue: 1 Linguagem: Inglês

10.3109/0284186x.2014.925140

1651-226X

Ana J. Molinari, Silvia I. Thorp, Agustina Mariana Portu, Gisela Saint Martin, Emiliano C. C. Pozzi, Elisa M. Heber, Silva Bortolussi, María E. Itoiz, Romina F. Aromando, Andrea Monti Hughes, Marcela A. Garabalino, S. Altieri, Verónica A. Trivillin, Amanda E. Schwint,

Medical Imaging Techniques and Applications

Background. We previously demonstrated the therapeutic success of sequential boron neutron capture therapy (Seq-BNCT) in the hamster cheek pouch oral cancer model. It consists of BPA-BNCT followed by GB-10-BNCT 24 or 48 hours later. Additionally, we proved that tumor blood vessel normalization with thalidomide prior to BPA-BNCT improves tumor control. The aim of the present study was to evaluate the therapeutic efficacy and explore potential boron microdistribution changes in Seq-BNCT preceded by tumor blood vessel normalization.