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BIBTEX RIS

Concise Total Synthesis of (−)‐Myxalamide A

2012; Wiley; Volume: 51; Issue: 29 Linguagem: Inglês

10.1002/anie.201203093

ISSN

1521-3773

Autores

Kazuhiro Fujita, Ryosuke Matsui, Takahiro Suzuki, Susumu Kobayashi,

Tópico(s)

Chemical synthesis and alkaloids

Resumo

The MIDA touch: A concise and highly convergent protecting-group-free total synthesis of (−)-myxalamide A involves a stereoselective vinylogous Mukaiyama aldol reaction of a vinylketene silyl N,O-acetal, together with a one-pot Stille/Suzuki–Miyaura cross-coupling reaction using Burke's N-methyliminodiacetic acid (MIDA) boronate to connect left- and right-hand fragments of the molecule (see scheme).

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