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High prevalence of low HDL cholesterol concentrations and mixed hyperlipidemia in a Mexican nationwide survey

2001; Elsevier BV; Volume: 42; Issue: 8 Linguagem: Inglês

10.1016/s0022-2275(20)31581-9

1539-7262

Carlos A. Aguilar‐Salinas, Gustavo Oláiz, Victoria Valles, Juan Torres, Francisco Javier Gómez Pérez, Juan Rull, Rosalba Rojas, Aurora Franco, Jaime Sepúlveda,

Adipokines, Inflammation, and Metabolic Diseases

The prevalence of lipid abnormalities revealed in a survey done in 417 Mexican cities is described. Information was obtained on 15,607 subjects, aged 20 to 69 years. In this report, only samples obtained after a 9- to 12-h fast were included (2,256 cases: 953 men and 1,303 women). The population is representative of Mexican urban adults. Mean lipid concentrations were: cholesterol, 4.80 mmol/l; triglycerides, 2.39 mmol/l; HDL cholesterol, 1.00 mmol/l; and LDL cholesterol, 3.06 mmol/l. The most prevalent abnormality was HDL cholesterol below 0.9 mmol/l (46.2% for men and 28.7% for women). Hypertriglyceridemia (>2.26 mmol/l) was the second most prevalent abnormality (24.3%). Severe hypertriglyceridemia (>11.2 mmol/l) was observed in 0.42% of the population. Increased LDL cholesterol (≥4.21 mmol/l) was observed in 11.2% of the sample. Half of the hypertriglyceridemic subjects had a mixed dyslipidemia or low HDL cholesterol. More than 50% of the low HDL cholesterol cases were not related to hypertriglyceridemia. Insulin resistance was found in 59% of them. In conclusion, the prevalence of hypoalphalipoproteinemia and other forms of dyslipidemia in Mexican adults is very high and it is among the highest previously reported worldwide. —Aguilar-Salinas, C. A., G. Olaiz, V. Valles, J. M. Ríos Torres, F. J. Gómez Pérez, J. A. Rull, R. Rojas, A. Franco, and J. Sepulveda. High prevalence of low HDL cholesterol concentrations and mixed hyperlipidemia in a Mexican nationwide survey.