Efficacy of Single-Dose Liposomal Amphotericin B or Micafungin Prophylaxis in a Neutropenic Murine Model of Invasive Pulmonary Aspergillosis
2008; American Society for Microbiology; Volume: 52; Issue: 11 Linguagem: Inglês
10.1128/aac.00715-08
ISSN1098-6596
AutoresRussell E. Lewis, Nathaniel D. Albert, Dimitrios P. Kontoyiannis,
Tópico(s)Infectious Diseases and Mycology
ResumoIn a neutropenic murine model of invasive pulmonary aspergillosis, prophylaxis with single doses of liposomal amphotericin B or micafungin at >or=5 mg/kg of body weight improved animal survival and suppressed the lung fungal burden for up to 7 days after infection, demonstrating the potential utility of infrequent dosing with these antifungals.
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