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CYP1A2 polymorphism (C > A at position −163) in Ovambos, Koreans and Mongolians

2006; Wiley; Volume: 25; Issue: 5 Linguagem: Inglês

10.1002/cbf.1336

1099-0844

Junko Fujihara, Kuninori Shiwaku, Yuing Xue, Kaori Kataoka, Yoko Hieda, Haruo Takeshita,

Glutathione Transferases and Polymorphisms

Abstract Cytochrome P450 1A2 ( CYP1A2 ) plays an important role in metabolizing drugs and xenobiotics, and is a possible participant in the development of several human diseases. Recent studies have shown that genetic polymorphism of −163 C > A single nucleotide mutation of CYP1A2 increases the risk of myocardial infarction and modulates CYP1A2 activity. In this study, we investigated the frequency of the −163 C > A mutation in Ovambos ( n = 177), Koreans ( n = 250) and Mongolians ( n = 153) and compared our results with other studies. Detection of this single nucleotide polymorphism was by polymerase chain reaction‐restriction fragment length polymorphism analysis (PCR‐RFLP). The frequencies of mutation ( CYP1A2*−163A ) in the Ovambos, Koreans and Mongolians were 0.46, 0.32 and 0.21, respectively. Ovambos showed a relatively higher frequency of mutation, similar to that of Tanzanians, while the Mongolians showed the lowest frequency of all study groups, including those from previous studies. This study is the first to investigate the distribution of the CYP1A2 (−163 C > A single nucleotide polymorphism) mutant allele in Ovambo, Korean and Mongolian populations. Copyright © 2006 John Wiley & Sons, Ltd.