MAGE-A3 expression is an adverse prognostic factor in diffuse large B-cell lymphoma
2011; Maney Publishing; Volume: 16; Issue: 6 Linguagem: Inglês
10.1179/102453311x13085644680384
ISSN1607-8454
AutoresIrma Olarte, Adolfo Martínez Tovar, Christian Omar Ramos Peñafiel, Humberto Castellanos-Sinco, Jorge Zamora, Juan Collazo-Jaloma, Mario Gutiérrez, Laila Gutiérrez‐Kobeh, Pedro Chávez-Olmos, Hugo Manzanilla, Efraín Garrido‐Guerrero, Rosa María Ordóñez‐Razo, E.I. Miranda,
Tópico(s)Vascular Tumors and Angiosarcomas
ResumoThis study evaluates the prognostic value of MAGE-A3 expression in 28 diffuse large B-cell lymphoma (DLBCL) patients. A significant association was observed between MAGE-A3 expressions, assessed by quantitative real-time RT-polymerase chain reaction (PCR), with advanced stages of disease (P < 0.05). Elevated serum lactate dehydrogenase (LDH) levels and International Prognostic Index (IPI) score were significantly higher in MAGE-A3-positive patients (P = 0.025 and P = 0.004, respectively). Expression of MAGE-A3 was associated with poor response to treatment and a significantly shorter overall survival (P < 0.001). Our data address new information in the association of MAGE-A3 expression and poor prognosis in DLBCL patients.
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