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GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

2013; American Association for the Advancement of Science; Volume: 340; Issue: 6139 Linguagem: Inglês

10.1126/science.1235488

1095-9203

Cornelius A. Rietveld, Sarah E. Medland, Jaime Derringer, Jian Yang, Tõnu Esko, Nicolás W. Martín, Harm-Jan Westra, Konstantin Shakhbazov, Abdel Abdellaoui, Arpana Agrawal, Eva Albrecht, Behrooz Z. Alizadeh, Najaf Amin, John Barnard, Sebastian E. Baumeister, Kelly S. Benke, Lawrence F. Bielak, Jeffrey A. Boatman, Patricia A. Boyle, Gail Davies, Christiaan de Leeuw, Niina Eklund, Daniel S. Evans, Rudolf Ferhmann, Krista Fischer, Christian Gieger, Håkon K. Gjessing, Sara Hägg, Jennifer R. Harris, Caroline Hayward, Christina Holzapfel, Carla A. Ibrahim‐Verbaas, Erik Ingelsson, Bo Jacobsson, Peter K. Joshi, Astanand Jugessur, Marika Kaakinen, Stavroula Kanoni, Juha Karjalainen, Ivana Kolčić, Kati Kristiansson, Zoltán Kutalik, Jari Lahti, Sang Lee, Pinpin Lin, Penelope A. Lind, Yongmei Liu, Kurt Lohman, Marisa Loitfelder, George McMahon, Pedro Marques‐Vidal, Osorio Meirelles, Lili Milani, Ronny Myhre, Marja-Liisa Nuotio, Christopher Oldmeadow, Katja Petrovic, Wouter J. Peyrot, Ozren Polašek, Lydia Quaye, Eva Reinmaa, John P. Rice, Thais S. Rizzi, Helena Schmidt, Reinhold Schmidt, Albert V. Smith, Jennifer A. Smith, Toshiko Tanaka, Antonio Terracciano, Matthijs J. H. M. van der Loos, Véronique Vitart, Henry Völzke, Jürgen Wellmann, Lei Yu, Wei Zhao, Jüri Allïk, John Attia, Stefania Bandinelli, François Bastardot, Jonathan Beauchamp, David A. Bennett, Kenneth I. Berger, Laura J. Bierut, Dorret I. Boomsma, Ute Bültmann, Harry Campbell, Christopher F. Chabris, Lynn Cherkas, Mina K. Chung, Francesco Cucca, Mariza de Andrade, Philip L. De Jager, Jan-Emmanuel De Neve, Ian J. Deary, George Dedoussis, Panos Deloukas, Maria Dimitriou, Guðný Eiríksdóttir, Martin F. Elderson, Johan G. Eriksson, David M. Evans, Jessica D. Faul, Luigi Ferrucci, Melissa E. Garcia, Henrik Grönberg, Vilmundur Guðnason, Per Hall, Juliette Harris, Tamara B. Harris, Nicholas D. Hastie, Andrew C. Heath, Dena Hernández, Wolfgang Hoffmann, Roelande Hofman, Rolf Holle, Elizabeth G. Holliday, Jouke‐Jan Hottenga, William G. Iacono, Thomas Illig, Marjo‐Riitta Järvelin, Mika Kähönen, Jaakko Kaprio, Robert M. Kirkpatrick, Matthew Kowgier, Antti Latvala, Lenore J. Launer, Debbie A. Lawlor, Terho Lehtimäki, Jingmei Li, Paul Lichtenstein, Peter Lichtner, David C. Liewald, Pamela A. F. Madden, Patrik K. E. Magnusson, Tomi Mäki‐Opas, Marco Masala, Matt McGue, Andres Metspalu, Andreas Mielck, Michael B. Miller, Grant W. Montgomery, Sutapa Mukherjee, Dale R. Nyholt, Ben A. Oostra, Lyle J. Palmer, Aarno Palotie, Brenda W.J.H. Penninx, Markus Perola, Patricia A. Peyser, Martin Preisig, Katri Räikkönen, Olli T. Raitakari, Anu Realo, Susan M. Ring, Samuli Ripatti, Fernando Rivadeneira, Igor Rudan, Aldo Rustichini, Veikko Salomaa, Antti-Pekka Sarin, David Schlessinger, Rodney J. Scott, Harold Snieder, Beaté St Pourcain, John M. Starr, Jae Hoon Sul, Ida Surakka, Rauli Svento, Alexander Teumer, Henning Tiemeier, Frank J.A. van Rooij, David R. Van Wagoner, Erkki Vartiainen, Jorma Viikari, Péter Vollenweider, Judith M. Vonk, Gérard Waeber, David R. Weir, H.‐Erich Wichmann, Elisabeth Widén, Gonneke Willemsen, James F. Wilson, Alan F. Wright, Dalton Conley, George Davey Smith, Lude Franke, Patrick J. F. Groenen, Albert Hofman, Magnus Johannesson, Sharon L. R. Kardia, Robert F. Krueger, David Laibson, Nicholas G. Martin, Michelle N. Meyer, Daniëlle Posthuma, Roy Thurik, Nicholas J. Timpson, André G. Uitterlinden, Cornelia M. van Duijn, Peter M. Visscher, Daniel J. Benjamin, David Cesarini, Philipp Koellinger,

Cognitive Abilities and Testing

Genetic College Many genomic elements in humans are associated with behavior, including educational attainment. In a genome-wide association study including more than 100,000 samples, Rietveld et al. (p. 1467 , published online 30 May; see the Perspective by Flint and Munafò ) looked for genes related to educational attainment in Caucasians. Small genetic effects at three loci appeared to impact educational attainment.