Chemical Constituents from Sambucus adnata and Their Protein-Tyrosine Phosphatase 1B Inhibitory Activities
2011; Pharmaceutical Society of Japan; Volume: 59; Issue: 11 Linguagem: Inglês
10.1248/cpb.59.1396
ISSN1347-5223
AutoresTatsunori Sasaki, Wei Li, Haruna Morimura, Songpei Li, Qin Li, Yoshihisa Asada, Kazuo Koike,
Tópico(s)Galectins and Cancer Biology
ResumoThe MeOH extract from the whole plants of Sambucus adnata has shown significant protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity. Chemical study on the extract resulted in the isolation of thirteen compounds, including a novel triterpene (1). The structure of 1 was determined to be 1α,3β-dihydroxy-urs-12-en-11-one-3-yl palmitate on the basis of extensive spectroscopic analyses. Among the isolated compounds, ursolic acid, oleanolic acid and (±)-boehmenan showed the most potent PTP1B inhibitory activity in vitro with the IC(50) values of 4.1, 14.4 and 43.5 µm, respectively. The kinetic analysis indicated that (±)-boehmenan inhibits PTP1B activity in a competitive manner.
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