A new general method for preparation of N-methoxy-N-methylamides. Application in direct conversion of an ester to a ketone
1995; Elsevier BV; Volume: 36; Issue: 31 Linguagem: Inglês
10.1016/0040-4039(95)01089-z
ISSN1873-3581
AutoresJ. Michael Williams, Ronald B. Jobson, Nobuyoshi Yasuda, George Marchesini, Ulf‐H. Dolling, Edward J. J. Grabowski,
Tópico(s)Chemical Reactions and Isotopes
ResumoThe reaction of an ester with N,O-dimethylhydroxylamine and a suitable organomagnesium reagent or lithium amide base provides a general method for the preparation of N-methoxy-N-methylamides. Application in the direct conversion of a highly hindered ester to a ketone, the azasteroid 5α-reductase inhibitor MK-0434, is described.
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