Transforming Growth Factor-β and Breast Cancer
1999; Springer Science+Business Media; Linguagem: Inglês
10.1007/978-1-59259-456-6_4
ISSN1880-4233
AutoresKatri Koli, Carlos L. Arteaga,
Tópico(s)Bone health and treatments
ResumoTransforming growth factor-ßs (TGF-ßs) and their receptor proteins are produced by most cell types. Signals generated by TGF-ß receptor-ligand interactions are involved in cell-growth regulation, development, morphogenesis, chemotaxis, and connective-tissue and extracellular-matrix production (1–3). TGF-β inhibits the growth of mammary epithelial cells and acts as an autocrine growth regulator. In stepwise tumor progression, the loss of TGF-ß responsiveness is thought to be a critical event in breast tumorigenesis. However, several carcinoma cells, although not always growth-inhibited by exogenous TGF-ß, may still exhibit modulation of their proteolytic and/or adhesive activities by added ligand. Often during breast cancer progression, tumor cells produce enhanced amount of TGF-ßs, which may provide an, albeit indirect, positive growth effect through enhanced angiogenesis, decreased host immune function, increase peritumoral-stroma formation, and cell adhesion. The cumulative data on this field suggest that the net effect of tumor cell TGF-ßs on the progression of breast carcinoma depends on the balance between the TGF-ßs-mediated autocrine growth inhibition of mammary tumor cells and the effects of the TGF-ßs on the host which indirectly foster tumor progression.
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