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Regulation of Dendritic Cell Migration by CD74, the MHC Class II-Associated Invariant Chain

2008; American Association for the Advancement of Science; Volume: 322; Issue: 5908 Linguagem: Inglês

10.1126/science.1159894

1095-9203

Gabrielle Faure-André, Pablo Vargas, María-Isabel Yuseff, Mélina L. Heuzé, Jheimmy Diaz, Danielle Lankar, Veronica Steri, Jérémy Manry, Stéphanie Hugues, Fulvia Vascotto, Jérôme Boulanger, Graça Raposo, Maria-Rosa Bono, Mario Rosemblatt, Matthieu Piel, Ana‐Maria Lennon‐Duménil,

Immune Cell Function and Interaction

Dendritic cells (DCs) sample peripheral tissues of the body in search of antigens to present to T cells. This requires two processes, antigen processing and cell motility, originally thought to occur independently. We found that the major histocompatibility complex II-associated invariant chain (Ii or CD74), a known regulator of antigen processing, negatively regulates DC motility in vivo. By using microfabricated channels to mimic the confined environment of peripheral tissues, we found that wild-type DCs alternate between high and low motility, whereas Ii-deficient cells moved in a faster and more uniform manner. The regulation of cell motility by Ii depended on the actin-based motor protein myosin II. Coupling antigen processing and cell motility may enable DCs to more efficiently detect and process antigens within a defined space.