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Self‐Liganded Suzuki–Miyaura Coupling for Site‐Selective Protein PEGylation

2013; Wiley; Volume: 52; Issue: 14 Linguagem: Inglês

10.1002/anie.201208626

1521-3773

Anaëlle Dumas, Christopher D. Spicer, Zhanghua Gao, Tsuyoshi Takehana, Yuya A. Lin, Tohru Yasukohchi, Benjamin G. Davis,

Carbohydrate Chemistry and Synthesis

Building with PEGs: PEG–boronic acids, in the presence of simple Pd sources, are capable of acting as direct and effective Suzuki reagents in 70–98 % yield. When combined with non-natural amino acids, they allow efficient and direct, site-selective PEGylation of proteins at predetermined positions under biologically compatible conditions without the need for exogenous ligands. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.