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Rhodium(i)-catalyzed hydroaminomethylation of 2-isopropenylanilines as a novel route to 1,2,3,4-tetrahydroquinolines

2007; Royal Society of Chemistry; Issue: 26 Linguagem: Inglês

10.1039/b702497e

1364-548X

Tiago O. Vieira, Howard Alper,

Asymmetric Hydrogenation and Catalysis

A new atom economical approach for the preparation of 1,2,3,4-tetrahydroquinolines can be achieved by means of the intramolecular hydroaminomethylation of 2-isopropenylanilines, mediated by an ionic diamino rhodium catalyst that does not require phosphine—this reaction is highly chemo- and regioselective, and it occurs in good isolated yields.