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A novel synthesis of purine and deazapurine derivatives from 5-aminoimidazoles

1989; Royal Society of Chemistry; Issue: 9 Linguagem: Inglês

10.1039/c39890000551

2050-5639

A. H. M. AL‐SHAAR, David W. Gilmour, David J. Lythgoe, I. McClenaghan, Christopher A. Ramsden,

DNA and Nucleic Acid Chemistry

Catalytic reduction of 4-unsubstituted-5-nitroimidazoles (3) in 1,4-dioxane solution is an excellent route to the 5-aminoimidazoles (1) which can be isolated or used in situ to generate good yields of purine or deazapurine derivatives.