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Antienvelope antibodies are protective against GBV-C reinfection: Evidence from the liver transplant model

1998; Wiley; Volume: 56; Issue: 3 Linguagem: Inglês

10.1002/(sici)1096-9071(199811)56

1096-9071

Howayda M. Hassoba, Mário G. Pessôa, Norah A. Terrault, Nancy J. Lewis, Mark Hayden, Jeffrey C. Hunt, Xiaoxing Qiu, Sheng C. Lou, Teresa L. Wright,

Liver Disease Diagnosis and Treatment

Journal of Medical VirologyVolume 56, Issue 3 p. 253-258 Antienvelope antibodies are protective against GBV-C reinfection: Evidence from the liver transplant model Howayda M. Hassoba, Howayda M. Hassoba Department of Medicine, University of California, San Francisco, California Department of Veterans Affairs Medical Center, University of California, San Francisco, CaliforniaSearch for more papers by this authorMario G. Pessoa, Mario G. Pessoa Department of Medicine, University of California, San Francisco, California Department of Veterans Affairs Medical Center, University of California, San Francisco, CaliforniaSearch for more papers by this authorNorah A. Terrault, Norah A. Terrault Department of Medicine, University of California, San Francisco, California Department of Veterans Affairs Medical Center, University of California, San Francisco, CaliforniaSearch for more papers by this authorNancy J. Lewis, Nancy J. Lewis Abbott Laboratories, Abbott Park, IllinoisSearch for more papers by this authorMark Hayden, Mark Hayden Abbott Laboratories, Abbott Park, IllinoisSearch for more papers by this authorJeffrey C. Hunt, Jeffrey C. Hunt Abbott Laboratories, Abbott Park, IllinoisSearch for more papers by this authorXiaoxing Qiu, Xiaoxing Qiu Abbott Laboratories, Abbott Park, IllinoisSearch for more papers by this authorSheng C. Lou, Sheng C. Lou Abbott Laboratories, Abbott Park, IllinoisSearch for more papers by this authorTeresa L. Wright, Corresponding Author Teresa L. Wright Department of Medicine, University of California, San Francisco, California Department of Veterans Affairs Medical Center, University of California, San Francisco, CaliforniaGastroenterology Section (111B), Veterans Administration Medical Center, 4150 Clement St., San Francisco, CA 94121===Search for more papers by this author Howayda M. Hassoba, Howayda M. Hassoba Department of Medicine, University of California, San Francisco, California Department of Veterans Affairs Medical Center, University of California, San Francisco, CaliforniaSearch for more papers by this authorMario G. Pessoa, Mario G. Pessoa Department of Medicine, University of California, San Francisco, California Department of Veterans Affairs Medical Center, University of California, San Francisco, CaliforniaSearch for more papers by this authorNorah A. Terrault, Norah A. Terrault Department of Medicine, University of California, San Francisco, California Department of Veterans Affairs Medical Center, University of California, San Francisco, CaliforniaSearch for more papers by this authorNancy J. Lewis, Nancy J. Lewis Abbott Laboratories, Abbott Park, IllinoisSearch for more papers by this authorMark Hayden, Mark Hayden Abbott Laboratories, Abbott Park, IllinoisSearch for more papers by this authorJeffrey C. Hunt, Jeffrey C. Hunt Abbott Laboratories, Abbott Park, IllinoisSearch for more papers by this authorXiaoxing Qiu, Xiaoxing Qiu Abbott Laboratories, Abbott Park, IllinoisSearch for more papers by this authorSheng C. Lou, Sheng C. Lou Abbott Laboratories, Abbott Park, IllinoisSearch for more papers by this authorTeresa L. Wright, Corresponding Author Teresa L. Wright Department of Medicine, University of California, San Francisco, California Department of Veterans Affairs Medical Center, University of California, San Francisco, CaliforniaGastroenterology Section (111B), Veterans Administration Medical Center, 4150 Clement St., San Francisco, CA 94121===Search for more papers by this author First published: 07 December 1998 https://doi.org/10.1002/(SICI)1096-9071(199811)56:3 3.0.CO;2-FCitations: 14AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract An assay for the detection of antibody against the second envelope (E2) protein of GB virus type C (GBV-C) has been developed. Early reports suggested that this antibody was a marker of viral clearance, yet it is unknown whether anti-E2 is protective against further GBV-C infection. The primary aims were to determine (1) if posttransplantation immunosuppression alters the prevalence of anti-E2; and (2) if anti-E2 positivity pretransplantation protects against acquisition of GBV-C infection posttransplantation. Fifty-four recipients who underwent orthotopic liver transplantation for end-stage liver disease of nonviral etiologies were tested for GBV-C RNA using a PCR-based assay and anti-E2 antibodies by an enzyme-linked immunoassay. Anti-E2 was present in 35% and in 46% of patients pre- and posttransplantation, respectively. Anti-E2 positivity pretransplantation was strongly associated with anti-E2 positivity after transplantation (P < 0.001); 83% of patients with anti-E2 prior to transplantation remained anti-E2–positive after transplantation. A negative association between presence of GBV-C viremia and presence of anti-E2 was found in all patients tested either prior to or following transplantation (P = 0.03). Acquisition of GBV-C infection was significantly lower in patients who were anti-E2–positive prior to transplantation (2/13) compared to those who were antiE2–negative (12/26) (P = 0.05). It is concluded that immunosuppression does not reduce the prevalence of anti-E2 after transplantation in those who are seroreactive prior to transplantation. Anti-E2 appears to be a neutralizing antibody whose presence at the time of liver transplantation protects against acquisition of GBV-C infection in the peritransplantation period. J. Med. Virol. 56:253–258, 1998. © 1998 Wiley-Liss, Inc. 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