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Antibacterial activities of erythromycins A, B, C, and D and some of their derivatives

1985; American Society for Microbiology; Volume: 28; Issue: 5 Linguagem: Inglês

10.1128/aac.28.5.630

1098-6596

IO Kibwage, Jos Hoogmartens, E. Roets, H. Vanderhaeghe, L. Verbist, M Dubost, C. Pascal, Patrice Petitjean, G. Levol,

Antibiotic Resistance in Bacteria

The MICs of erythromycins A, B, C, and D and some of their derivatives were determined against 21 gram-positive and 15 gram-negative microorganisms. Antibacterial activity was confined to gram-positive and very few gram-negative bacteria. Erythromycin B was somewhat less active than erythromycin A, and erythromycin C and D showed about half that activity or even less. Most other derivatives had negligible activity. Determination of potency by diffusion and turbidimetric assays were in line with MICs. The examination of the results of these assays, however, revealed that there are differences between the data of different laboratories, depending on the microorganisms and conditions used.