Effects of long-term antihypertensive treatment on cerebral, thalamic and cerebellar blood flow in spontaneously hypertensive rats (SHR).
1986; Lippincott Williams & Wilkins; Volume: 17; Issue: 5 Linguagem: Inglês
10.1161/01.str.17.5.985
ISSN1524-4628
AutoresMotonobu Fujishima, Setsuro Ibayashi, Kenichi Fujii, Hiroshi Yao, Seizo Sadoshima,
Tópico(s)Optical Imaging and Spectroscopy Techniques
ResumoCerebral blood flows (CBF) were measured in the parietal cortex, the thalamus and the cerebellum by the hydrogen clearance technique in anesthetized spontaneously hypertensive rats, of which hypertension was treated for 16 weeks (long-term) or 8 weeks (short-term) with antihypertensive agents of hydralazine and guanethidine. As compared to non-treated control animals, CBF in the three regions were significantly increased while the calculated cerebrovascular resistances (CVR) were decreased in hypertension-treated animals. Such CBF and CVR changes were greater in SHR with long-term than short-term therapy. Both an increase in CBF and a decrease in CVR were closely related to a fall in the blood pressure. From the present results, it was concluded that earlier and longer treatment of hypertension could lessen or even prevent the increased CVR due to the hypertensive vascular changes, and increase CBF as a result.
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