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Giant cell reaction to ameloblastoma: An immunohistochemical and ultrastructural study of a case

1989; Elsevier BV; Volume: 47; Issue: 7 Linguagem: Inglês

10.1016/s0278-2391(89)80017-5

1531-5053

Toshiyuki Kawakami, Motoyoshi Antoh, Toshikazu Minemura,

Bone and Dental Protein Studies

Summary Histopathologic, immunohistochemical, and ultrastructural features of the giant cells appearing in the tissue surrounding an ameloblastoma are presented. These giant cells exhibited strong activity of a highly stable form of acid phosphatase, and were positive for α-1-antichymotrypsin. Ultrastructurally, the cytoplasm of the giant cells contained numerous mitochondria, and the cell membrane was comparatively smooth. Therefore, it is proposed that these multinucleated giant cells are reactive to the invasion of ameoloblastoma and are histiocytic in origin.