Hiccups as an Adverse Reaction to Cancer Chemotherapy
2002; Oxford University Press; Volume: 94; Issue: 10 Linguagem: Inglês
10.1093/jnci/94.10.772
ISSN1460-2105
Autores Tópico(s)Phytochemistry and Bioactive Compounds
ResumoAlthough most research reports on cancer chemotherapy have shown no data on the occurrence of hiccups as an adverse reaction, several reports (1–3) have disclosed a high incidence of hiccups, i.e., in more than 30% of treated patients during chemotherapy. Because most cancer chemotherapy regimens consist of multiple drugs, including cytotoxic agents, 5-hydroxytryptamine 3 (5-HT3) receptor antagonists, and corticosteroids, identifying the causative drug is very difficult. Of those drugs, dexamethasone, which is used for the prophylaxis of delayed emesis, has already been shown to cause hiccups (4), although other drugs, including chemotherapeutic agents, cannot be ruled out. To determine the frequency of hiccups associated with the use of specific
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