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BIBTEX RIS

Interleukin 18 in the CNS

2010; BioMed Central; Volume: 7; Issue: 1 Linguagem: Inglês

10.1186/1742-2094-7-9

ISSN

1742-2094

Autores

Silvia Alboni, Davide Cervia, Shuei Sugama, Bruno Conti,

Tópico(s)

Dermatology and Skin Diseases

Resumo

Abstract Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavior. Work on IL-18 null mice, the localization of the IL-18 receptor complex in neurons and the neuronal expression of decoy isoforms of the receptor subunits are beginning to reveal the complexity and the significance of the IL-18 system in the CNS. This review summarizes current knowledge on the central role of IL-18 in health and disease.

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