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Dogs as alternative intermediate hosts of Taenia solium in Papua (Irian Jaya), Indonesia confirmed by highly specific ELISA and immunoblot using native and recombinant antigens and mitochondrial DNA analysis

2002; Cambridge University Press; Volume: 76; Issue: 4 Linguagem: Inglês

10.1079/joh2002128

1475-2697

Akira Ito, M.I. Putra, Rizal Subahar, Marcello Otake Sato, Masanori Okamoto, Yasuhito Sako, Miki Nakao, Hiroshi Yamasaki, Kazuhiro Nakaya, Philip S. Craig, Sri S. Margono,

Parasitic Infections and Diagnostics

Abstract Serology (ELISA and immunoblot) using native glycoproteins, affinity purified glycoproteins, and a recombinant antigen is known to be highly specific to Taenia solium cysticercosis in humans and pigs. These techniques were applied for dogs in the highly endemic area of cysticercosis in Papua (Irian Jaya), Indonesia. Analysis of dog sera by both ELISA and immunoblot revealed 7 of 64 dogs were highly positive. Examination of two sero-positive dogs revealed cysticerci of T. solium in the brain and heart of these dogs. Mitochondrial DNA analysis confirmed that they were the same as T. solium previously confirmed from pigs and biopsies from local people from Irian Jaya. It is suggested that the life cycle of T. solium may be completed not only between humans and pigs but also between humans and dogs.