Portal de Periódicos da CAPES

Risk of Heart Failure With Human Immunodeficiency Virus in the Absence of Prior Diagnosis of Coronary Heart Disease

2011; American Medical Association; Volume: 171; Issue: 8 Linguagem: Inglês

10.1001/archinternmed.2011.151

1538-3679

Adeel A. Butt, Chung‐Chou H. Chang, Lewis H. Kuller, Matthew Bidwell Goetz, David A. Leaf, David Rimland, Cynthia L. Gibert, Krisann K. Oursler, Maria C. Rodriguez‐Barradas, Joseph K. Lim, Lewis E. Kazis, Stephen S. Gottlieb, Amy C. Justice, Matthew S. Freiberg,

HIV Research and Treatment

Background: Whether human immunodeficiency virus (HIV) infection is a risk factor for heart failure (HF) is not clear.The presence of coronary heart disease and alcohol consumption in this population may confound this association.Methods: To determine whether HIV infection is a risk factor for incident HF, we conducted a populationbased, retrospective cohort study of HIV-infected and HIVuninfected veterans enrolled in the Veterans Aging Cohort Study Virtual Cohort (VACS-VC) and the 1999 Large Health Study of Veteran Enrollees (LHS) from January 1, 2000, to July 31, 2007.Results: There were 8486 participants (28.2% HIVinfected) enrolled in the VACS-VC who also participated in the 1999 LHS.During the median 7.3 years of follow-up, 286 incident HF events occurred.Age-and race/ethnicity-adjusted HF rates among HIV-infected and HIV-uninfected veterans were 7.12 (95% confidence interval [CI],6.90-7.34)and 4.82 (95% CI, 4.72-4.91)per