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CAN PERINEURAL INVASION ON PROSTATE NEEDLE BIOPSY PREDICT PROSTATE SPECIFIC ANTIGEN RECURRENCE AFTER RADICAL PROSTATECTOMY?

1999; Lippincott Williams & Wilkins; Volume: 162; Issue: 1 Linguagem: Inglês

10.1097/00005392-199907000-00025

1527-3792

Alexandre de la Taille, Mark A. Rubin, Emilia Bagiella, Carl A. Olsson, Ralph Buttyan, Tatjana Burchardt, Charles Knight, Kathleen O’Toole, A E Katz,

Prostate Cancer Treatment and Research

No AccessJournal of UrologyClinical Urology: Original Articles1 Jul 1999CAN PERINEURAL INVASION ON PROSTATE NEEDLE BIOPSY PREDICT PROSTATE SPECIFIC ANTIGEN RECURRENCE AFTER RADICAL PROSTATECTOMY? ALEXANDRE de la TAILLE, MARK A. RUBIN, EMILIA BAGIELLA, CARL A. OLSSON, RALPH BUTTYAN, TATJANA BURCHARDT, CHARLES KNIGHT, KATHLEEN M. O'TOOLE, and AARON E. KATZ ALEXANDRE de la TAILLEALEXANDRE de la TAILLE , MARK A. RUBINMARK A. RUBIN , EMILIA BAGIELLAEMILIA BAGIELLA , CARL A. OLSSONCARL A. OLSSON , RALPH BUTTYANRALPH BUTTYAN , TATJANA BURCHARDTTATJANA BURCHARDT , CHARLES KNIGHTCHARLES KNIGHT , KATHLEEN M. O'TOOLEKATHLEEN M. O'TOOLE , and AARON E. KATZAARON E. KATZ View All Author Informationhttps://doi.org/10.1097/00005392-199907000-00025AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated the role of perineural invasion identified on prostate needle biopsy as a predictor of prostate specific antigen (PSA) recurrence after radical prostatectomy. Materials and Methods: Between 1993 and 1998 radical prostatectomy was performed in 319 consecutive patients. Prostate needle biopsies were reviewed in all cases. We compared perineural invasion with other preoperative parameters, including digital rectal examination, PSA and biopsy Gleason score, for the ability to predict PSA recurrence with recurrence defined as any serum PSA level greater than 0.2 ng./ml. Results: Perineural invasion was identified on 77 of 319 preoperative prostate biopsies (24%). There was PSA recurrence in 46 patients (14.4%) at a mean followup of 25.4 months (range 0.2 to 62.1). Perineural invasion statistically correlated with PSA recurrence. Kaplan-Meier analysis revealed disease-free survival rates of 24 versus 64% when perineural invasion was and was not present in the prostate biopsy (p = 0.0003, log rank 12.92). Multivariate analysis demonstrated that perineural invasion (p = 0.012) and PSA (p = 0.005) were independent preoperative predictive factors of PSA recurrence. When perineural invasion was compared with postoperative parameters, including disease stage, surgical margins and seminal vesicle invasion, it was not an independent predictor because it closely correlated with tumor stage. Conclusions: Perineural invasion on preoperative prostate needle biopsy is a strong independent predictor of PSA recurrence in patients in whom prostate cancer was treated with radical prostatectomy. References 1 : The use of prostatic specific antigen, clinical stage and Gleason score to predict pathological stage in men with localized prostate cancer. J. Urol.1993; 150: 110. Abstract, Google Scholar 2 : Radical prostatectomy. Patterns of local failure and survival in 67 patients. Urology1988; 31: 191. Google Scholar 3 : Prognostic significance of positive surgical margins in radical prostatectomy specimens. J. Urol.1995; 154: 1818. Link, Google Scholar 4 : Serum PSA after anatomic radical prostatectomy. The Johns Hopkins experience after 10 years. Urol. Clin. N. Amer.1993; 20: 713. Google Scholar 5 : The incidence and significance of detectable levels of serum prostate specific antigen after radical prostatectomy. J. Urol.1994; 152: 1821. Link, Google Scholar 6 : Long-term (15 years) results after radical prostatectomy for clinically localized (stage T2c or lower) prostate cancer. J. Urol.1994; 152: 1850. Link, Google Scholar 7 : Prostate-specific antigen after anatomic radical retropubic prostatectomy. Patterns of recurrence and cancer control. Urol. Clin. N Amer.1997; 24: 395. Google Scholar 8 : The prostatic capsule: does it exist? Its importance in the staging and treatment of prostatic carcinoma. Amer. J. Surg. Path.1989; 13: 21. Google Scholar 9 : Influence of capsular penetration on progression following radical prostatectomy: a study of 196 cases with long-term followup. J. Urol.1993; 150: 135. Link, Google Scholar 10 : Carcinoma of the prostate: prognostic evaluation of certain pathologic features in 208 radical prostatectomies. Examined by step-section technique. Cancer1972; 30: 5. Google Scholar 11 : Diagnostic criteria of limited adenocarcinoma of the prostate on needle biopsy. Hum. Path.1995; 26: 223. Google Scholar 12 : Carcinoma of the prostate gland: a pathologic study. J. Urol.1939; 41: 224. Google Scholar 13 : Spread of adenocarcinoma within prostatic ducts and acini: morphologic and clinical correlations. Amer. J. Surg. Path.1996; 20: 802. Google Scholar 14 : The role of perineural space invasion in the local spread of prostatic adenocarcinoma. J. Urol.1989; 142: 763. Link, Google Scholar 15 : Relationship between perineural tumor invasion on needle biopsy and radical prostatectomy capsular penetration in clinical stage B adenocarcinoma of the prostate. Amer. J. Surg. Path.1993; 17: 336. Google Scholar 16 : Prediction of extraprostatic extension of prostate cancer based on needle biopsy findings: perineural invasion lacks significance on multivariate analysis. Amer. J. Surg. Path.1997; 21: 1496. Google Scholar 17 : Comparison of magnetic resonance imaging and ultrasonography in staging early prostate cancer. Results of a multi-institutional cooperative trial. New Engl. J. Med.1990; 323: 621. Google Scholar 18 : Correlation of prostate needle biopsy and radical prostatectomy Gleason grade in academic and community settings. Amer. J. Surg. Path.1997; 21: 566. Google Scholar 19 : Systematic biopsies accurately predict extracapsular extension of prostate cancer and persistent/recurrent detectable PSA after radical prostatectomy. Urology1994; 44: 371. Google Scholar 20 : Prostate cancer staging: correlation between ultrasound determined tumor contact length and pathologically confirmed extraprostatic extension. J. Urol.1998; 159: 1251. Link, Google Scholar 21 de la Taille, A., Katz, A.E., Bagiella, E., Olsson, C.A., O'Toole, K.M., Rubin, M.A., Perineural invasion on prostate needle biopsy: an independent predictor of final pathology, unpublished data. Google Scholar 22 : The role of perineural invasion and other biopsy characteristics as prognostic markers for localized prostate cancer. Sem. Urol. Oncol.1998; 16: 124. Google Scholar From the Squier Urological Clinic, College of Physicians and Surgeons and Department of Biostatistics, School of Public Health, Columbia University, and Departments of Urology and Pathology, Columbia-Presbyterian Medical Center, New York, New YorkSupported by National Institutes of Health, National Cancer Institute Grant ROI CA 70769, MSD-Merck (Bourse de l'Association Francaise d'Urologie-MSD) and Exchange Visitor Program Lavoisier (Ministere des Affaires Etrangeres, France).(Katz) Requests for reprints: Columbia-Presbyterian Medical Center, The Atchley Pavilion, 11th Floor, Room 1153, 161 Fort Washington Ave., New York, New York 11032.© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited bySHARIAT S, KHODDAMI S, SABOORIAN H, KOENEMAN K, SAGALOWSKY A, CADEDDU J, McCONNELL J, HOLMES M and ROEHRBORN C (2018) Lymphovascular Invasion is a Pathological Feature of Biologically Aggressive Disease in Patients Treated With Radical ProstatectomyJournal of Urology, VOL. 171, NO. 3, (1122-1127), Online publication date: 1-Mar-2004.SHAH O, ROBBINS D, MELAMED J and LEPOR H (2018) The New York University Nerve Sparing Algorithm Decreases the Rate of Positive Surgical Margins Following Radical Retropubic ProstatectomyJournal of Urology, VOL. 169, NO. 6, (2147-2152), Online publication date: 1-Jun-2003.FREEDLAND S, CSATHY G, DOREY F and ARONSON W (2018) PERCENT PROSTATE NEEDLE BIOPSY TISSUE WITH CANCER IS MORE PREDICTIVE OF BIOCHEMICAL FAILURE OR ADVERSE PATHOLOGY AFTER RADICAL PROSTATECTOMY THAN PROSTATE SPECIFIC ANTIGEN OR GLEASON SCOREJournal of Urology, VOL. 167, NO. 2 Part 1, (516-520), Online publication date: 1-Feb-2002.EPSTEIN J and POTTER S (2018) THE PATHOLOGICAL INTERPRETATION AND SIGNIFICANCE OF PROSTATE NEEDLE BIOPSY FINDINGS: IMPLICATIONS AND CURRENT CONTROVERSIESJournal of Urology, VOL. 166, NO. 2, (402-410), Online publication date: 1-Aug-2001.D'AMICO A, WU Y, CHEN M, NASH M, RENSHAW A and RICHIE J (2018) PERINEURAL INVASION AS A PREDICTOR OF BIOCHEMICAL OUTCOME FOLLOWING RADICAL PROSTATECTOMY FOR SELECT MEN WITH CLINICALLY LOCALIZED PROSTATE CANCERJournal of Urology, VOL. 165, NO. 1, (126-129), Online publication date: 1-Jan-2001. Volume 162Issue 1July 1999Page: 103-106 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.MetricsAuthor Information ALEXANDRE de la TAILLE More articles by this author MARK A. RUBIN More articles by this author EMILIA BAGIELLA More articles by this author CARL A. OLSSON More articles by this author RALPH BUTTYAN More articles by this author TATJANA BURCHARDT More articles by this author CHARLES KNIGHT More articles by this author KATHLEEN M. O'TOOLE More articles by this author AARON E. KATZ More articles by this author Expand All Advertisement PDF downloadLoading ...