Lipid Rafts, Detergent-Resistant Membranes, and Raft Targeting Signals
2006; American Physiological Society; Volume: 21; Issue: 6 Linguagem: Inglês
10.1152/physiol.00032.2006
ISSN1548-9213
Autores Tópico(s)RNA and protein synthesis mechanisms
ResumoLipid rafts are liquid-ordered (l(o)) phase microdomains proposed to exist in biological membranes. Rafts have been widely studied by isolating l(o)-phase detergent-resistant membranes (DRMs) from cells. Recent findings have shown that DRMs are not the same as preexisting rafts, prompting a major revision of the raft model. Nevertheless, raft-targeting signals identified by DRM analysis are often required for protein function, implicating rafts in a variety of cell processes.
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