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Effect of intravenous taurine supplementation on plasma, blood cell, and urine taurine concentrations in adults undergoing long-term parenteral nutrition

1990; Elsevier BV; Volume: 52; Issue: 5 Linguagem: Inglês

10.1093/ajcn/52.5.846

1938-3207

Kopple Jd, NE Vinton, SA Laidlaw, ME Ament,

Hernia repair and management

Thirty-four adults undergoing long-term parenteral nutrition (TPN) were treated either with or without intravenous taurine for ≤ 24 mo. Statistical comparisons were carried out in eight patients randomly assigned to receive intravenous taurine, usually 10 mg⋅kg−1⋅d−1, and 10 patients not receiving taurine. Compared with normal adults, baseline plasma taurine and urine taurine-creatinine ratios were decreased in both groups and platelet taurine was reduced in the taurine-treated group. During taurine treatment the mean of the mean values for taurine became normal in plasma and platelets and remained normal in erythrocytes, granulocytes, and lymphocytes; urine taurine-creatinine ratios rose to approximately five times normal. During follow-up, patients not given taurine had plasma, erythrocyte, and granulocyte taurine and urine taurine-creatinine ratios below normal values and the concentrations of taurine-treated patients. Their platelet taurine was also subnormal. Thus, 10 mg taurine⋅kg−1⋅d−1intravenously normalizes plasma and blood cell taurine concentrations in long-term TPN patients.