Transformation of aucubin to new pyridine monoterpene alkaloids, aucubinines A and B, by human intestinal bacteria
1990; Wiley; Volume: 4; Issue: 2 Linguagem: Inglês
10.1002/ptr.2650040207
ISSN1099-1573
AutoresMasao Hattori, Yukio Kawata, Kazuyo Inoue, Yue‐Zhong Shu, Qing‐Ming Che, Tsuneo Namba, Kyoichi Kobashi,
Tópico(s)Drug-Induced Hepatotoxicity and Protection
ResumoAbstract Aucubin was transformed to new nitrogen‐containing compounds named aucubinines A and B, along with an aglycone, aucubigenin by anaerobic incubation with defined strains of human intestinal bacteria and with faecal flora of humans. Among 24 bacterial strains examined, Klebsiella pneumoniae, Bifidobacterium breve, Bifidobacterium pseudolongum, Peptostreptococcus intermedius and Bacteroides fragilis showed potent ability of transforming aucubin to aucubinine A. Aucubinines A and B were prepared from aucubin by almond β‐glucosidase in the presence of NH .
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