Two pools of β-endorphin-like immunoreactivity in blood: Plasma and erythrocytes
1984; Elsevier BV; Volume: 34; Issue: 19 Linguagem: Inglês
10.1016/0024-3205(84)90677-5
ISSN1879-0631
AutoresAlice Fisher, Marcella Comly, Robert Do, Lawrence Temarkin, Amir F. Ghazanfari, Anil B. Mukherjee,
Tópico(s)Hypothalamic control of reproductive hormones
ResumoWhile attempting to delineate the reason for the reported extreme variability of beta-endorphin-like immunoreactivity (beta-ir) in human plasma (eg., nondetectable to 1 ng/ml) by standard radioimmunoassay, we noted that a substantial portion of circulating beta-ir was associated with erythrocytes. That erythrocyte associated beta-ir is authentic beta-endorphin (beta-EP) was confirmed by high performance liquid chromatography (HPLC). Analysis of blood samples from rabbits, rats and mice revealed the presence of beta-ir in erythrocytes from these species as well. These results suggest that there are two pools of beta-endorphin-like immunoreactivity in blood: plasma and erythrocytes.
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