In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein
2013; Elsevier BV; Volume: 108; Linguagem: Inglês
10.1016/j.colsurfb.2013.02.032
ISSN1873-4367
AutoresMadalena Martins, Nuno G. Azóia, Artur Ribeiro, Ulyana Shimanovich, Carla Silva, Artur Cavaco‐Paulo,
Tópico(s)Proteins in Food Systems
ResumoTransdermal perfusion of a large protein is reported for the first time, using a nanoemulsion of bovine serum albumin (66 kDa) of 160 nm prepared by a solid-in-oil (S/O) process. Molecular dynamics simulations confirmed skin permeation by these formulations, with integration of the protein into the lipid bilayers. These results demonstrate the real possibility of delivering large proteins transdermally for a range of medical and cosmetic applications.
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