Portal de Periódicos da CAPES

Association of Diabetes With Prostate Cancer Risk in the Multiethnic Cohort

2009; Oxford University Press; Volume: 169; Issue: 8 Linguagem: Inglês

10.1093/aje/kwp003

1476-6256

Katrina M. Waters, B. E. Henderson, Daniel O. Stram, Peng Wan, Laurence N. Kolonel, C. A. Haiman,

Diabetes, Cardiovascular Risks, and Lipoproteins

Among men of European ancestry, diabetics have a lower risk of prostate cancer than do nondiabetics.The biologic basis of this association is unknown.The authors have examined whether the association is robust across populations in a population-based prospective study.The analysis included 5,941 prostate cancer cases identified over a 12-year period (1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005) among 86,303 European-American, African-American, Latino, Japanese-American, and Native Hawaiian men from the Multiethnic Cohort.The association between diabetes and prostatespecific antigen (PSA) levels (n ¼ 2,874) and PSA screening frequencies (n ¼ 46,970) was also examined.Diabetics had significantly lower risk of prostate cancer than did nondiabetics (relative risk ¼ 0.81, 95% confidence interval (CI): 0.74, 0.87; P < 0.001), with relative risks ranging from 0.65 (95% CI: 0.50, 0.84; P ¼ 0.001) among European Americans to 0.89 (95% CI: 0.77, 1.03; P ¼ 0.13) among African Americans.Mean PSA levels were significantly lower in diabetics than in nondiabetics (mean PSA levels, 1.07 and 1.28, respectively; P ¼ 0.003) as were PSA screening frequencies (44.7% vs. 48.6%;P < 0.001); however, this difference could explain only a small portion (~20%) of the inverse association between these diseases.Diabetes is a protective factor for prostate cancer across populations, suggesting shared risk factors that influence a common mechanism.cohort studies; diabetes mellitus, type 2; ethnology; prostate-specific antigen;