Dam methylation: coordinating cellular processes
2005; Elsevier BV; Volume: 8; Issue: 2 Linguagem: Inglês
10.1016/j.mib.2005.02.009
ISSN1879-0364
AutoresAnders Løbner‐Olesen, Ole Skovgaard, Martin Marinus,
Tópico(s)Legume Nitrogen Fixing Symbiosis
ResumoGATC sequences in Escherichia coli DNA are methylated at the adenine residue by DNA adenine methyltransferase (DamMT). These methylated residues and/or the level of DamMT can influence cellular functions such as gene transcription, DNA mismatch repair, initiation of chromosome replication and nucleoid structure. In certain bacteria, unlike E. coli, DamMT is essential for viability perhaps owing to its role in chromosome replication. DamMT has also been implicated as a virulence factor in bacterial pathogenesis. The origin and phylogeny of DamMT, based on sequenced genomes, has been deduced.
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