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Withdrawal symptoms from phenytoin, carbamazepine and sodium valproate.

1988; BMJ; Volume: 51; Issue: 7 Linguagem: Inglês

10.1136/jnnp.51.7.924

1468-330X

John S. Duncan, Simon Shorvon, M. Trimble,

Neurological and metabolic disorders

A prospective, double-blind, placebo-controlled investigation of possible withdrawal symptoms from phenytoin, carbamazepine and sodium valproate is reported in patients with active epilepsy, on combination therapy. There was an increase in seizures on reduction and withdrawal of carbamazepine, but there was no convincing evidence of withdrawal symptoms from any of these drugs.