SYNTHESIS OF γ‐METHYL‐ l ‐LEUCINE (NEOPENTYLGLYCINE, NEO) AND DERIVATIVES SUITABLE FOR PEPTIDE SYNTHESIS
1981; Wiley; Volume: 18; Issue: 3 Linguagem: Inglês
10.1111/j.1399-3011.1981.tb02979.x
ISSN0367-8377
AutoresJean‐Luc Fauchère, Claudia Petermann,
Tópico(s)Receptor Mechanisms and Signaling
ResumoThe modified Strecker synthesis of Patel & Worsley was combined with an enzymatic deamidation in the final step, to produce the title compound. The amino acid is a member of the family of the “fat” amino‐acids with high lipophilicity and space‐filling properties, as estimated by its Hansch hydrophobicity constant and its Charton steric parameter v. It can be used for qualitative and quantitative studies of structure‐activity relationships in biologically active peptides. Three of its derivatives suitable for peptide synthesis are also described.
Referência(s)