Phosphine‐Free, Palladium‐Catalyzed Arylation of Heterocycles through CH Bond Activation with Pivalic Acid as a Cocatalyst
2008; Wiley; Volume: 15; Issue: 6 Linguagem: Inglês
10.1002/chem.200802001
ISSN1521-3765
AutoresDongbing Zhao, Weida Wang, Shuang Lian, Fei Yang, Jingbo Lan, Jingsong You,
Tópico(s)Sulfur-Based Synthesis Techniques
ResumoChemistry – A European JournalVolume 15, Issue 6 p. 1337-1340 Communication Phosphine-Free, Palladium-Catalyzed Arylation of Heterocycles through CH Bond Activation with Pivalic Acid as a Cocatalyst Dongbing Zhao, Dongbing Zhao Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (P.R. China), Fax: (+86) 28-85412203Search for more papers by this authorWeida Wang, Weida Wang Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (P.R. China), Fax: (+86) 28-85412203Search for more papers by this authorShuang Lian, Shuang Lian Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (P.R. China), Fax: (+86) 28-85412203Search for more papers by this authorFei Yang, Fei Yang Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (P.R. China), Fax: (+86) 28-85412203Search for more papers by this authorJingbo Lan Prof. Dr., Jingbo Lan Prof. Dr. Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (P.R. China), Fax: (+86) 28-85412203Search for more papers by this authorJingsong You Prof. Dr., Jingsong You Prof. Dr. [email protected] Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (P.R. China), Fax: (+86) 28-85412203Search for more papers by this author Dongbing Zhao, Dongbing Zhao Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (P.R. China), Fax: (+86) 28-85412203Search for more papers by this authorWeida Wang, Weida Wang Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (P.R. China), Fax: (+86) 28-85412203Search for more papers by this authorShuang Lian, Shuang Lian Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (P.R. China), Fax: (+86) 28-85412203Search for more papers by this authorFei Yang, Fei Yang Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (P.R. China), Fax: (+86) 28-85412203Search for more papers by this authorJingbo Lan Prof. Dr., Jingbo Lan Prof. Dr. Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (P.R. China), Fax: (+86) 28-85412203Search for more papers by this authorJingsong You Prof. Dr., Jingsong You Prof. Dr. [email protected] Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (P.R. China), Fax: (+86) 28-85412203Search for more papers by this author First published: 20 January 2009 https://doi.org/10.1002/chem.200802001Citations: 90Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Ligand-free C-arylation: A general palladium-catalyzed C-arylation of N-heterocycles with aryl bromides has been performed without the presence of phosphines, the aid of CuI, or other metal additives by using pivalic acid as a cocatalyst (see scheme). Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description chem_200802001_sm_miscellaneous_information.pdf1.3 MB miscellaneous information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1For reviews, see: 1aJ. C. Lewis, R. G. Bergman, J. A. 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