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Changes in Human Erythrocyte Membrane Proteins During Storage

1971; Wiley; Volume: 20; Issue: 3 Linguagem: Inglês

10.1111/j.1423-0410.1971.tb00435.x

1423-0410

Gerald L. Moore, Donald A. Cooper, Ross S. Antonoff, S. Robinson,

Blood properties and coagulation

Abstract. Changes in erythrocyte membrane proteins during storage are presented as possibly reducing structural integrity of the membrane and leading to hemolysis. Various separation procedures and physicochemical methods were used to compare the membrane proteins obtained from fresh and from 21‐day‐old (outdated) erythrocytes. The proteins prepared from these two sources were found to differ with respect to net charge, electrophoretic and chromatographic separation patterns, and conformation (three‐dimensional structure).