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Assessment of anaesthesia depth

1996; Wiley; Volume: 40; Issue: 9 Linguagem: Inglês

10.1111/j.1399-6576.1996.tb05570.x

1399-6576

Tom Heier, Petter Andreas Steen,

Hemodynamic Monitoring and Therapy

Acta Anaesthesiologica ScandinavicaVolume 40, Issue 9 p. 1087-1100 Assessment of anaesthesia depth T. Heier, Corresponding Author T. Heier Department of Anesthesiology, Ullevaal University Hospital, Oslo, NorwayDepartment of Anesthesiology Ullevaal University Hospital 0407 Oslo, NorwaySearch for more papers by this authorP. A. Steen, P. A. Steen Department of Anesthesiology, Ullevaal University Hospital, Oslo, NorwaySearch for more papers by this author T. Heier, Corresponding Author T. Heier Department of Anesthesiology, Ullevaal University Hospital, Oslo, NorwayDepartment of Anesthesiology Ullevaal University Hospital 0407 Oslo, NorwaySearch for more papers by this authorP. A. Steen, P. A. Steen Department of Anesthesiology, Ullevaal University Hospital, Oslo, NorwaySearch for more papers by this author First published: October 1996 https://doi.org/10.1111/j.1399-6576.1996.tb05570.xCitations: 54AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Stanski DR. Monitoring depth of anesthesia. In: RD Miller, ed. Anesthesia, Vol. II. New York: Churchill Livingstone, 1994: 1127–1159. 2 Prys-Roberts C. Anesthesia: A practical or impractical construct? Br J Anaesth 1987: 59: 1341–1345. 3 Kissin I. General anesthetic action: An obsolete notion? Anesth Analg 1993: 76: 215–18. 4 Heier T., Steen PA. Awareness in Anaesthesia. Acta Anaesthesiol Scand 1996. In press. 5 Sebel PS. Are our patients listening? ASA Newsletter (American Society of Anesthesiologists) 1994: 58: 7–9. 6 Weinberger NM, Gold PE, Sternberg DB. Epinephrine enables Pavlovian fear conditioning under anesthesia. Science 1984: 223: 605–607. 7 Griffith D., Jones JG. Awareness and memory in anesthetized patients. Br J Anaesth 1990: 65: 603–606. 8 Newton DER Depth of anesthesia. Anesthesia 1993. 48: 367–368. 9 Dwyer R., Bennett HL, Eger EI II, Heilbron D. Effects of isoflurane and nitrous oxide in subanesthetic concentrations on memory and responsiveness in volunteers. Anesthesiology 1992: 77: 888–898. 10 Jones JG, Konieczko K. Hearing and memory in anesthetized patients. Br Med J 1986: 292: 1291–1293. 11 Newton DEF, Thornton C., Konieczko K., Frith CD, Doré CJ, Webster NR, et al. Level of consciousness in volunteers breathing sub-MAC concentrations of isoflurane. Br J Anaesth 1990: 65: 609–615. 12 Ghoneim MM, Block RI. Learning and consciousness during general anesthesia. Anesthesiology 1992: 76: 279–305. 13 Schacter DL. Implicit memory: History and current status. J Exp Psych Learn Mem Cogn 1987: 13: 501–518. 14 Squire LR. Mechanisms of memory. Science 1986: 232: 1612–1619. 15 Jordening H., Pedersen T. The incidence of conscious awareness in a general population of anesthetized patients. Anesthesiology 1991: 75: A1055. 16 Saucier N., Walts LF, Moreland JR. Patient awareness during nitrous oxide, oxygen and halothane anesthesia. Anesth Analg 1983: 62: 239–240. 17 Sebel PS. Awareness during anesthesia: An introduction. ASA Newsletter (American Society of Anesthesiologists) 1994: 58: 7–9. 18 Yakaitis RW, Blitt CD, Angiulo JP. End-tidal halothane concentration for endotracheal intubation. Anesthesiology 1977: 47: 386–388. 19 Yakaitis RW, Blitt CD, Angiulo JP. End-tidal enflurane concentration for endotracheal intubation. Anesthesiology 1979: 50: 59–61. 20 Stoelting RK, Longnecker DE, Eger EI II. Minimum alveolar concentrations in humans on awakening from methoxyflurane, halothane, ether and fluroxene anesthesia. Anesthesiology 1970: 33: 5–9. 21 Roizen MF, Horrigan RW, Frazer BM. Anesthetic doses blocking adrenergic (stress) and cardiovascular responses to incision - MAC bar. Anesthesiology 1981: 54: 390–398. 22 Stanski DR. Monitoring depth of anesthesia. In: RD Miller, ed. Anesthesia. New York: Churchill Livingstone, 1990: 1001–1029. 23 Ausems ME, Hug CC, de Lange S. Variable rate infusion of alfentanil as a supplement to nitrous oxide anesthesia for general surgery. Anesth Analg 1983: 62: 982–986. 24 Ausems ME, Hug CC, Stanski DR, Burm AGL. Plasma concentrations of alfentanil required to supplement nitrous oxide anesthesia for general surgery. Anesthesiology 1986: 65: 362–273. 25 Ausems ME, Vuyk J., Hug CC, Stanski DR. Comparison of a computer-assisted infusion vs. intermittent bolus administration of alfentanil as a supplement to nitrous oxide for lower abdominal surgery. Anesthesiology 1988: 68: 851–861. 26 Zbinden AM, Maggiorini M., Petersen-Felix S., Lauber R., Thomson DA, Minder CE. Anesthetic depth defined using multiple noxious stimuli during isoflurane/oxygen anesthesia. I. Motor reactions. Anesthesiology 1994: 80: 253–260. 27 Chortkoff BS, Gonsowski CT, Bennett HL, Levinson B., Crankshaw DP, Dutton RC, et al. Learning of relevant information is suppressed by sub-MAC anesthesia. Memory and Awareness in Anaesthesia. Third Int Symposium, Rotterdam 1995: 15 (abstract). 28 Chortkoff BS, Eger EI II, Bennett HL, Crankshaw DP, Gonsowski CT, Dutton RC, et al. Learning of matter-of-fact information is suppressed at MAC-awake. Memory and Awareness in Anaesthesia. Third Int Symposium, Rotterdam 1995: 36 (abstract). 29 Dutton RC, Smith WD, Smith Ty N. Wakeful response to command indicates memory potential during emergence from general anesthesia. J Clin Monit 1995: 11: 35–40. 30 Dutton RC, Smith WD, Smith Ty N. Brief wakeful response to command indicates wakefulness with suppression of memory formation during surgical anesthesia. J Clin Monit 1995: 11: 41–46. 31 Dwyer R., Bennett HL, Eger EI II, Peterson N. Isoflurane anesthesia prevents unconscious learning. Anesth Analg 1992: 75: 107–112. 32 Zbinden AM, Petersen-Felix S., Thomson DA. Anesthetic depth defined using multiple noxious stimuli during isoflurane/oxygen anesthesia. II. Hemodynamic responses. Anesthesiology 1994: 80: 261–267. 33 Yasuda N., Weiskopf RB, Cahalan MK, Ionescu P., Caldwell JE, Eger EI II, et al. Does desflurane modify circulatory responses to stimulations in humans? Anesth Analg 1991: 73: 175–179. 34 Kotrly KJ, Ebert TJ, Vucins E., Igler FO, Barney JA, Kampine JP. Baroreceptor reflex control of heart rate during isoflurane anesthesia in humans. Anesthesiology 1984: 60: 173–179. 35 Duke PC, Trosky S. The effect of halothane with nitrous oxide on baroreflex control of heart rate in man. Can Anaesth Soc J 1980: 27: 531–534. 36 Cullen DJ, Eger EI II, Stevens WC, Smith Ty N., Cromwell TH, Cullen BF, et al. Clinical signs of anesthesia. Anesthesiology 1972: 36: 21–36. 37 Stanski DR, Shafer SL. Quantifying anesthetic drug interaction. Implications for drug dosing. Anesthesiology 1995: 83: 1–5. 38 Veselis RA, Reinsel RA, Feshchenko VA, Wronski M., Dnistrian A., Dutchers S., et al. Impaired memory and behavioral performance with fentanyl at low plasma concentrations. Anesth Analg 1994: 79: 952–960. 39 Lowenstein E., Hallowell P., Levine FH, Daggett WM, Austen WG, Laver MB. Cardiovascular response to large doses of intravenous morphine in man. N Engl J Med 1969: 281: 1389–1393. 40 Lowenstein E. Morphine 'anesthesia' - a perspective. Anesthesiology 1971: 35: 563–565. 41 Lowenstein E., Philbin DM. Narcotic 'anesthesia' in the eighties. Anesthesiology 1981: 55: 195–197. 42 Streisand JB, Bailey PL, LeMaire L., Ashburn MA, Tarver SD, Varvel J., et al. Fentanyl-induced rigidity and unconsciousness in human volunteers. Anesthesiology 1993: 78: 629–634. 43 McDonnell TE, Bartkowski RR, Williams JJ. ED50 of alfentanil for induction of anesthesia in unpremedicated young adults. Anesthesiology 1984: 60: 136–140. 44 de Lange S., de Bruijn NP. Alfentanil-oxygen anaesthesia: Plasma concentrations and clinical effects during variablerate continuous infusion for coronary artery surgery. Br J Anaesth 1983: 55: 183S–189S. 45 Bowdle TA, Ward RJ. Induction of anesthesia with small doses of sufentanil: Dose vs. EEG response, speed of onset, and thiopental requirement. Anesthesiology 1989: 70: 26–30. 46 Bailey PL, Stanley TH Are opioids anesthetics? Intravenous Opioid Anesthesia. In: RD Miller, ed. Anesthesia, Vol II. New York: Churchill Livingstone, 1994: 300–303. 47 Dodson BA, Miller KW. Evidence for a dual mechanism in the anesthetic action of an opioid peptide. Anesthesiology 1985: 62: 615–620. 48 Bailey PL, Port JD, McJames S., Reinersman L., Stanley TH. Is fentanyl an anesthetic in the dog? Anesth Analg 1987: 66: 542–548. 49 Hug CC, Hall RI, Angert KC, Reeder DA, Moldenhauer CC. Alfentanil plasma concentration v. effect relationship in cardiac surgical patients. Br J Anaesth 1988: 61: 435–440. 50 Murphy MR, Hug CC. The anesthetic potency of fentanyl in terms of its reduction of enflurane MAC. Anesthesiology 1982: 57: 485–488. 51 McEwan AI, Smith C., Dyar O., Goodman D., Smith LR, Glass PSA. Isoflurane minimum alveolar concentration reduction by fentanyl. Anesthesiology 1993: 78: 864–869. 52 Hall RL Murphy MR, Hug CC Jr. The enflurane sparing effect of sufentanil in dogs. Anesthesiology 1987: 67: 518–525. 53 Hecker BR, Lake CL, DiFazio CA, Moscicki JC, Engle JS. The decrease of the minimum alveolar anesthetic concentration produced by sufentanil in rats. Anesth Analg 1983: 62: 987–990. 54 Wong KC. Narcotics are not expected to produce unconsciousness and amnesia. Anesth Analg 1983: 62: 625–626. 55 Waller JL, Hug CC Jr, Nagle DM, Craver JM. Hemodynamic changes during fentanyl-oxygen anesthesia for aortacoronary bypass operation. Anesthesiology 1981: 55: 212–217. 56 Wynands JE, Wong P., Townsend GE, Sprigge JS, Whalley DG. Narcotic requirements for intravenous anesthesia. Anesth Analg 1984: 63: 101–105. 57 Samuelson PN, Reves JG, Kirklin JK, Bradley E. Jr, Wilson KD, Adams M. Comparison of sufentanil and enflurane-nitrous oxide anesthesia for myocardial revascularization. Anesth Analg 1986: 65: 217–226. 58 Philbin DM, Rosow CE, Schneider RC, Koski G., D'Ambra MN. Fentanyl and sufentanil anesthesia revisited: How much is enough? Anesthesiology 1990: 73: 5–11. 59 Glass PSA, Doherty M., Jacobs JR, Goodman D., Smith LR. Plasma concentration of fentanyl, with 70% nitrous oxide, to prevent movement at skin incision. Anesthesiology 1993: 78: 842–847. 60 Hung OR, Varvel JR, Shafer SL, Stanski DR. Thiopental pharmacodynamics. Anesthesiology 1992: 77: 237–244. 61 Vuyk J., Engbers FHM, Lemmens HJM, Burm AGL, Vletter AA, Gladines MPRR, et al. Pharmacodynamics of propofol in female patients. Anesthesiology 1992: 77: 3–9. 62 Dunnet JM, Prys-Roberts C., Holland DE, Browne BL. Propofol infusion and the suppression of consciousness: Dose requirements to induce loss of consciousness and to suppress response to noxious and non-noxious stimuli. Br J Anaesth 1994: 72: 29–34. 63 Smith C., McEwan AI, Jhaveri J., Wilkinson M., Goodman D., Canada A., et al. Reduction of propofol Cp50 by fentanyl. Anesthesiology 1992: 77: A340 (abstract). 64 Spelina KR, Coates DP, Monk CR, Prys-Roberts C., Norley I., Turtle MJ. Dose requirements of propofol by infusion during nitrous oxide anaesthesia in man. Br J Anaesth 1986: 58: 1080–1084. 65 Vuyk J., Lim T., Engbers FHM, Burm AGL, Vletter AA, Bovill JG. Pharmacodynamics of alfentanil as a supplement to propofol or nitrous oxide for lower abdominal surgery in female patients. Anesthesiology 1993: 78: 1036–1045. 66 Tunstall ME. Detecting wakefulness during general anaesthesia for caesarean section. Br Med J 1977: 274: 1321. 67 King H., Ashley S., Brathwaite D., Decayette J., Wooten DJ. Adequacy of general anesthesia for cesarean section. Anesth Analg 1993: 77: 84–88. 68 Russel IF. Balanced anesthesia: Does it anesthetize? Anesth Analg 1985: 64: 941–942. 69 Russel IF. Comparison of wakefulness with two anaesthetic regimens. Br J Anaesth 1986: 58: 965–968. 70 Russel IF. Midazolam-alfentanil: An anaesthetic? An investigation using the isolated forearm technique. Br J Anaesth 1993: 70: 42–46. 71 Schultetus RR, Hill CR, Dharamraj CM, Banner TE, Berman LS. Wakefulness during cesarean section after induction with ketamine, thiopental, or ketamine and thiopental combined. Anesth Analg 1986: 65: 723–728. 72 Wilson ME. Awareness in general anaesthesia. Br Med J 1980: 280: 1270. 73 Tunstall ME. Sleep phobia after awareness during general anaesthesia: Treatment by induced wakefulness. Br Med J 1982: 285: 865. 74 Breckenridge JL, Aitkenhead AR. Awareness during anaesthesia: a review. Ann Roy Coll Surg Engl 1983: 65: 93–96. 75 Bogod DG, Orton JK, Oh TE. Detecting awareness during general anaesthetic caesarean section. Anaesthesia 1990: 45: 279–284. 76 Breckenridge JL, Aitkenhead AR. Isolated forearm technique for detection of wakefulness during general anaesthesia. Br J Anaesth 1981: 53: 665P–666P. 77 Tunstall ME. The reduction of amnesic wakefulness during caesarean section. Anaesthesia 1979: 34: 316–319. 78 Russel IF. Auditory perception under anaesthesia. Anaesthesia 1979: 34: 211. 79 Russel IF. Awareness in general anaesthesia. Br Med J 1980: 280: 1056. 80 Christensen J. Motor functions of the pharynx and oesophagus. In: LR Johnson, ed. Physiology of the gastrointestinal tract, 2nd edn. Vol. I. New York: Raven Press, 1987: 595–612. 81 Rubin J., Nagler R., Spiro HM, Pilot ML. Measuring the effect of emotions on esophageal motility. Psychosom Med 1962: 24: 170–176. 82 Schwieger IM, Hall RI, Hug CC Jr. Assessing the adequacy of fentanyl anaesthesia: Plasma concentrations and lower oesophageal contractility. Acta Anaesthesiol Scand 1991: 35: 227–234. 83 Thomas DI, Aitkenhead AR. Relationship between lower oesophageal contractility and type of surgical stimulation. Br J Anaesth 1990: 64: 306–310. 84 Evans JM, Bithell JF, Vlachonikolis IG. Relationship between lower oesophageal contractility, clinical signs and halothane concentration during general anaesthesia and surgery in man. Br J Anaesth 1987: 59: 1346–1355. 85 Raftery S., Enever G., Prys-Roberts C. Oesophageal contractility during total IV anaesthesia with and without glycopyrronium. Br J Anaesth 1991: 66: 566–571. 86 Sessler DI, Støen R., Olofsson CI, Chow F. Lower esophageal contractility predicts movement during skin incision in patients anesthetized with halothane, but not with nitrous oxide and alfentanil. Anesthesiology 1989: 70: 42–46. 87 Mather C., Raftery S., Prys-Roberts C. Somatic movement and oesophageal motility during isoflurane anaesthesia. Br J Anaesth 1992: 69: 40–44. 88 Erickson JP, Foss J., Kurd DR. A controlled trial of efficacy of lower esophageal contractility as a measure of depth of anesthesia. Anesthesiology 1987: 67: A672 (abstract). 89 Aitkenhead AR, Lin ES, Thomas D. Relationship between lower esophageal contractility and clinical signs of light anesthesia. Anesthesiology 1987: 67: A671 (abstract). 90 Cox PN, White DC. Do oesophageal contractions measure "depth" of anaesthesia? Br J Anaesth 1986: 58: 131P–132P. 91 Isaac PA, Rosen M. Lower oesophageal contractility and detection of awareness during anaesthesia. Br J Anaesth 1990: 65: 319–324. 92 Harmel MH, Klein FF, Davis DA. The EEMG - a practical index of cortical activity and muscular relaxation. Acta Anaesthesiol Scand 1978: 70: 97–102. 93 Paloheimo M., Edmonds HL Jr., Wirtavuori K., Tammisto T. Assessment of anaesthetic adequacy with upper facial and abdominal wall EMG. Eur J Anaesthesiol 1989: 6: 111–119. 94 Tammisto T., Toikka O. Spontaneous EMG activity for detection of arousal during general anaesthesia-comparison between recordings from frontal and neck musculature. Eur J Anaesthesiol 1991: 8: 109–114. 95 Tammisto T., Olkkola KT. Dependence of the adequacy of muscle relaxation on the degree of neuromuscular block and depth of enflurane anesthesia during abdominal surgery. Anesth Analg 1995: 80: 543–547. 96 Tammisto T. Neuromuscular block vs. muscle relaxation: Clinical applications of the difference. Finnanest 1992: 18: 11–18. 97 Edmonds HL, Yli-Hankala A., Heine MF, Tsueda K., Strickland TJ. Anesthetic adequacy, surface EMG and quantitated EEG. Acta Anaesthesiol Scand 1993: 37: 102–104. 98 Tammisto T. Anaesthetic adequacy and auditory evoked potentials. Acta Anaesthesiol Scand 1993: 37: 109–110. 99 Gibbs FA, Gibbs EL, Lennox WG. Effect on the electro-encephalogram of certain drugs which influence nervous activity. Arch Intern Med 1987: 60: 154. 100 Levy WJ, Shapiro HM, Maruchak G., Meathe E. Automated EEG processing for intraoperative monitoring: A comparison of techniques. Anesthesiology 1980: 53: 223–236. 101 Gregory TK, Pettus DC. An electroencephalographic processing algorith specifically intended for analysis of cerebral electrical activity. J Clin Monit 1986: 2: 191–197. 102 Kochs E., Bischoff P., Pichlmeier U., Esch Schulteam J. Surgical stimulation induced changes in brain electrical activity during isoflurane-nitrous oxide anesthesia. Anesthesiology 1994: 80: 1026–1034. 103 International Federation of Societies of Electroencephalography and Clinical Neurophysiology: Recommendations for the practice of clinical neurophysiology. Amsterdam: Elsevier, 1983: 13. 104 Rosner BS, Clark DL. Neurophysiologic effects of general anesthetics. Anesthesiology 1973: 39: 59–81. 105 Clark DL, Rosner BS. Neurophysiologic effects of general anesthetics. Anesthesiology 1973: 38: 564–582. 106 Hudson RJ, Stanski DR, Saidman LJ, Meathe E. A model for studying depth of anesthesia and acute tolerance to thiopental. Anesthesiology 1983: 59: 301–308. 107 Long CW, Shah NK, Loughlin C., Spydell J., Bedford RF. A comparison of EEG determinants of near-awakening from isoflurane and fentanyl anesthesia. Anesth Analg 1989: 69: 169–173. 108 Drummond JC, Brann CA, Perkins DE, Wolfe DE. A comparison of median frequency, spectral edge frequency, a frequency band power ratio, total power, and dominance shift in the determination of depth of anesthesia. Acta Anaesthesiol Scand 1991: 35: 693–699. 109 Schwilden H., Stoeckel H. Quantitative EEG analysis during anaesthesia with isoflurane in nitrous oxide at 1.3 and 1.5 MAC Br J Anaesth 1987: 59: 738–745. 110 Schwilden H., Schuettler J., Stoeckel H. Closed-loop feedback control of methohexital anesthesia by quantitative EEG analysis in humans. Anesthesiology 1987: 67: 341–347. 111 Schwilden H., Stoeckel H., Schuettler J. Closed-loop feedback control of propofol anaesthesia by quantitative EEG analysis in humans. Br J Anaesth 1989: 62: 290–296. 112 Scott JC, Ponganis KV, Stanski DR. EEG quantitation of narcotic effect: The comparative pharmacodynamics of fentanyl and alfentanil. Anesthesiology 1985: 62: 234–241. 113 Hering W., Geisslinger G., Kamp HD, Dinkel M., Tschaikowski K., Ruegheimer E., et al. Changes in the EEG power spectrum after midazolam anaesthesia combined with racemic or S-(+) ketamine. Acta Anaesthesiol Scand 1994: 38: 719–723. 114 Sebel PS, Bovill JG, Wauquier A., Rog P. Effects of high-dose fentanyl anesthesia on the electroencephalogram. Anesthesiology 1981: 55: 203–211. 115 Herregods L., Roily G., Mortier E., Bogaert M., Mergaert C. EEG and SEMG monitoring during induction and maintenance of anesthesia with propofol. Int J Clin Monit Comput 1989: 6: 67–73. 116 Engelhardt W., Carl G., Dierks T., Maurer K. Electroencephalographic mapping during isoflurane anesthesia for treatment of mental depression. J Clin Monit 1991: 7: 23–29. 117 Veselis RA, Reinsel RA, Marino P., Wronski M. EG power spectrum changes during propofol sedation. Anesthesiology 1991: 75: A181 (abstract). 118 Forrest FC, Tooley MA, Saunders PR, Prys-Roberts C. Propofol infusion and the suppression of consciousness: The EEG and dose requirements. Br J Anaesth 1994: 72: 35–41. 119 Rampil IJ. What neuroanesthesiologists should know about electroencephalograms and computerized monitors. Anesthesiol Clin North Am 1992: 10: 683. 120 Levy WJ. Power spectrum correlates of changes in consciousness during anesthetic induction with enflurane. Anesthesiology 1986: 64: 688–693. 121 Black S., Mahla ME, Cucchiara RF. Neurologic monitoring. In: RD Miller, ed. Anesthesia, Vol. II. New York: Churchill Livingstone, 1994: 1319–1344. 122 Plourde G. Depth of anaesthesia. Can J Anaesth 1991: 38: 270–274. 123 Plourde G., Picton TW. Long-latency auditory evoked potential during general anesthesia: N1 and P3 components. Anesth Analg 1991: 72: 342–50. 124 Dwyer RC, Rampil IJ, Eger EI II, Bennett HL. The electroencephalogram does not predict depth of isoflurane anesthesia. Anesthesiology 1994: 81: 403–409. 125 Spencer EM, Green JL, Willatts SM. Continuous monitoring of depth of sedation by EEG spectral analysis in patients requiring mechanical ventilation. Br J Anaesth 1994: 73: 649–654. 126 Shah NK, Long CW, Bedford RF. 'Delta-shift': An EEG sign of awakening during light isoflurane anesthesia. Anesth Analg 1988: 67: S266 (abstract). 127 Cooke JE, Scott JC. Theta ratio: A better correlate of anesthetic depth. Anesthesiology 1986: 65: A541. 128 Rampil IJ, Laster MJ. No correlation between quantitative electroencephalographic measurements and movement response to noxious stimuli during isoflurane anesthesia in rats. Anesthesiology 1992: 77: 920–925. 129 Rampil IJ, Mason P., Singh H. Anesthetic potency (MAC) is independent of forebrain structures in the rat. Anesthesiology 1993: 78: 707–712. 130 Rampil I. Anesthetic potency is not altered after hypothermic spinal cord transection in rats. Anesthesiology 1994: 80: 606–610. 131 Kendig JJ. Spinal cord as a site of anesthetic action. Anesthesiology 1993: 79: 1161–1162. 132 King BS, Rampil IJ. Anesthetic depression of spinal motor neurons may contribute to lack of movement response to noxious stimuli. Anesthesiology 1994: 81: 1484–1492. 133 Barnett TP, Johnson LC, Naitoh P., Hicks N., Nute C. Bispectrum analysis of electroencephalogram, signals during waking and sleeping. Science 1971: 172: 401–402. 134 Dumermuth G., Huber PJ, Kleiner B., Gasser T. Analysis of the interrelations between frequency bands of the EEG by means of the bispectrum. A preliminary study. Electroencephal Clin Neurophysiol 1971: 31: 137–148. 135 Vernon JM, Lang E., Sebel PS, Manberg P. Prediction of movement using bispectral electroencephalographic analysis during propofol-alfentanil or isoflurane-alfentanil anesthesia. Anesth Analg 1995: 80: 780–785. 136 Kearse LA, Manberg P., Chamoun N., deBros F., Zaslavsky A. Bispectral analysis of the encephalogram correlates with patient movement to skin incision during propofol-nitrous oxide anesthesia. Anesthesiology 1994: 81: 1365–1370. 137 Rampil IJ, Matteo RS. Changes in EEG spectral edge frequency correlate with the hemodynamic response to laryngoscopy and intubation. Anesthesiology 1987: 67: 139–142. 138 White PF, Boyle WA. Relationship between hemodynamic and electroencephalographic changes during general anesthesia. Anesth Analg 1989: 68: 177–181. 139 Bovill JG, Sebel PS, Wauquier A., Rog P., Schuyt HC. Influence of high-dose alfentanil anaesthesia on the electroencephalogram: Correlation with plasma concentrations. Br J Anaesth 1983: 55: 199S–209S. 140 Oshima E., Shingu K., Mori K. EEG activity during halothane anaesthesia in man. Br J Anaesth 1981: 53: 65–72. 141 Bimar J., Bellville JW. Arousal reactions during anesthesia in man. Anesthesiology 1977: 47: 449–454. 142 Wilder-Smith OHG, Hagon O., Tassonyi E. EEG arousal with laryngoscopy and intubation during induction with nitrous oxide and propofol or thiopentone. Eur J Anaesth 1994: 11: A224 (abstract). 143 Kochs E., Bischoff P., Esch Schulteam J. Topographical analysis of EEG frequency descriptors in isoflurane-nitrous oxide anesthetized patients. Anesthesiology 1993: 79: A174 (abstract). 144 Grundy BL. Intraoperative monitoring of sensory-evoked potentials. Anesthesiology 1983: 58: 72–87. 145 Koht A. Anesthesia and evoked potentials: Overview. Int J Clin Monit Comput 1988: 5: 167–173. 146 Bailey PL, Stanley TH. Opioid action and sensory evoked potentials. In: RD Miller, ed. Anesthesia, Vol. II. New York: Churchill Livingstone, 1994: 320. 147 Mason DG, Higgins D., Boyd SG, Lloyd-Thomas AR. Effects of isoflurane anaesthesia on the median nerve somatosensory evoked potential in children. Br J Anaesth 1992: 69: 562–566. 148 Mason DG, Higgins D., Boyd SG, Lloyd-Thomas AR. Sequential measurement of the median nerve somatosensory evoked potential during isoflurane anaesthesia in children. Br J Anaesth 1992: 69: 567–569. 149 Porkkala T., Jaentti V., Kaukinen S., Haekkinen V. Somatosensory evoked potentials during isoflurane anaesthesia. Acta Anaesthesiol Scand 1994: 38: 206–210. 150 Sebel PS, Glass P., Neville WK. Do evoked potentials measure depth of anaesthesia? Int J Clin Monit Comput 1988: 5: 163–166. 151 Thornton C., Creagh-Barry P., Jordan C., Luff NP, Doré CJ, Henley M., et al. Somatosensory and auditory evoked responses recorded simultaneously: Differential effects of nitrous oxide and isoflurane. Br J Anaesth 1992: 68: 508–514. 152 Sebel PS, Ingram DA, Flynn PJ, Rutherfoord CF, Rogers H. Evoked potentials during isoflurane anaesthesia. Br J Anaesth 1986: 58: 580–585. 153 Sebel PS, Flynn PJ, Ingram DA. Effect of nitrous oxide on visual, auditory and somatosensory evoked potentials. Br J Anaesth 1984: 56: 1403–1407. 154 Thornton C., Catley DM, Jordan C., Lehane JR, Royston D., Jones JG. Enflurane anaesthesia causes graded changes in the brainstem and early cortical auditory evoked response in man. Br J Anaesth 1983: 55: 479–483. 155 Thornton C., Heneghan CPH, James MFM, Jones JG. Effects of halothane or enflurane with controlled ventilation on auditory evoked potentials. Br J Anaesth 1984: 56: 315–322. 156 Thornton C., Barrowcliffe MP, Konieczko KM, Ventham P., Doré CJ, Newton DEF, et al. The auditory evoked response as an indicator of awareness. Br J Anaesth 1989: 63: 113–115. 157 Thornton C., Creagh-Barry P., Jordan C., Newton DEF. Anaesthetic depth and auditory evoked potentials. Acta Anaesthesiol Scand 1993: 37: 105–108. 158 Schmidt JF, Chraemmer-Joergensen Auditory evoked potentials during isoflurane anaesthesia. Acta Anaesthesiol Scand 1986: 30: 378–380. 159 Heneghan CPH, Thornton C., Navaratnarajah M., Jones JG. Effect of isoflurane on the auditory evoked response in man. Br J Anaesth 1987: 59: 277–282. 160 Schwender D., Rimkus T., Haessler R., Klasing S., Poeppel E., Peter K. Effect of increasing doses of alfentanil, fentanyl and morphine on mid-latency auditory evoked potentials. Br J Anaesth 1993: 71: 622–628. 161 Schwender D., Klasing S., Madler C., Poeppel E., Peter K. Mid-latency auditory evoked potentials during ketamine anaesthesia in humans. Br J Anaesth 1993: 71: 629–632. 162 Schwender D., Klasing S., Madler C., Poeppel E., Peter K. Midlatency auditory evoked potentials and purposeful movements after thiopentone bolus injection. Anaesthesia 1994: 49: 99–104. 163 Schwender D., Faber-Zuellig E., Klasing S., Poeppel E., Peter K. Motor signs of wakefulness during general anaesthesia with propofol, isoflurane and flunitrazepam/fentanyl and midlatency auditory evoked potentials. Anaesthesia 1994: 49: 476–484. 164 Schwender D., Weninger E., Daunderer M., Klasing S., Poeppel E., Peter K. Anesthesia with increasing doses of sufentanil and midlatency auditory evoked potentials in humans. Anesth Analg 1995: 80: 499–505. 165 Schwender D., Kaiser A., Klasing S., Peter K. Explicit and implicit memory and mid-latency auditory evoked potentials during cardiac surgery. Anesth Analg 1992: 74: S269 (abstract). 166 Hett DA, Smith DC, Pilkington SN, Abbott TR. Effect of temperature on the auditory evoked response. Br J Anaesth 1994: 72: 487P. 167 Munglani R., Andrade J., Sapsford DJ, Baddeley A., Jones JG. A measure of consciousness and memory during isoflurane administration: The coherent frequency. Br J Anaesth 1993: 71: 633–641. 168 Picton TW, Hillyard SA, Krausz HI, Galambos R. Human auditory evoked potentials. I: Evaluation of components. Electroenchephal Clin Neurophysiol 1974: 36: 179–190. 169 Jessop J., Jones JG. Conscious awareness during general anesthesia - what are we attempting to monitor? Br J Anaesth 1991: 66: 635–637. 170 Madler C., Keller I., Schwender D., Poeppel E. Sensory information processing during general anaesthesia: Effect of isoflurane on auditory evoked neuronal oscillations. Br J Anaesth 1991: 66: 81–87. 171 Newton DEF, Thornton C., Creagh-Barry P., Doré CJ. Early cortical auditory evoked response in anaesthesia: Comparison of the effects of nitrous oxide and isoflurane. Br J Anaesth 1989: 62: 61–65. 172 Schwender D., Klasing S., Faber-Zuellig E., Peter K. Effects of thiopentone on mid-latency auditory evoked potentials. Anesth Analg 1992: 74: S270 (abstract). 173 Navaratnarajah M., Thornton C., Heneghan CPH, Batsman PE, Jones JG. Effect of etomidate on the auditory evoked response in man. Br J Anaesth 1983: 55: 1157P. 174 Schwender D., Haessler R., Klasing S., Madler C., Poeppel E., Peter K. Mid-latency auditory evoked potentials and circulatory response to loud sounds. Br J Anaesth 1994: 72: 307–314. 175 Newton DEF, Thornton C., Konieczko KM, Jordan C., Webster NR, Luff NP, et al. Auditory evoked response and awareness: A study in volunteers at sub-MAC concentrations of isoflurane. Br J Anaesth 1992: 69: 122–129. 176 Schwender D., Kaiser A., Klasing S., Peter K., Poeppel E. Mid-latency auditory evoked potentials and explicit and implicit memory in patients undergoing cardiac surgery. Anesthesiology 1994: 80: 493–501. 177 Schwender D., Klasing S., Madler C., Poeppel E., Peter K. Mid-latency auditory evoked potentials indicate wakefulness during caesarean section. Eur J Anaesth 1994: 11: 147–148. 178 Thornton C., Konieczko K., Jones JG, Jordan C., Doré CJ, Heneghan CPH. Effect of surgical stimulation on the auditory evoked response. Br J Anaesth 1988: 60: 372–378. 179 Jessop J., Griffiths DE, Furness P., Jones JG, Sapsford DJ, Breckon DA. Changes in amplitude and latency of the P300 component of the auditory evoked potential with sedative and anaesthetic concentrations of nitrous oxide. Br J Anaesth 1991: 67: 524–531. 180 Reinsel RA, Veselis RA, Wronski M., Marino P. The P300 event-related potential during propofol sedation: A possible marker for amnesia? Br J Anaesth 1995: 74: 674–680. 181 Sneyd JR, Samra SK, Davidson B., Kishimoto T., Kadoya C., Domino EF. Electropysiologic effects of propofol sedation. Anesth Analg 1994: 79: 1151–1158. 182 Musiek FE, Geurkink NA, Weider DJ, Donnelly K. Past, present, and future applications of the auditory middle latency response. Laryngoscope 1984: 94: 1545–1553. 183 Plourde G., Picton TW. Human auditory steady-state response during general anesthesia. Anesth Analg 1990: 71: 460–468. 184 Plourde G., Boylan JF. The auditor steady state response during sufentanil anaesthesia. Br J Anaesth 1991: 66: 683–691. 185 Yli-Hankala A., Edmonds HL, Heine MF, Strickland T., Tsueda K. Auditory steady-state response, upper fascial EMG, EEG and heart rate as predictors of movement during isofluran. 186 Jones JG. Coherent frequency of the EEG: Validation of an auditory steady state response method. Acta Anaesthesiol Scand 1993: 37: 99–101. Citing Literature Volume40, Issue9October 1996Pages 1087-1100 ReferencesRelatedInformation