Accelerated Decline of Aerobic Fitness With Healthy Aging
2005; Lippincott Williams & Wilkins; Volume: 112; Issue: 5 Linguagem: Inglês
10.1161/circulationaha.105.553321
ISSN1524-4539
AutoresPhilip A. Ades, Michael J. Toth,
Tópico(s)Balance, Gait, and Falls Prevention
ResumoHomeCirculationVol. 112, No. 5Accelerated Decline of Aerobic Fitness With Healthy Aging Free AccessEditorialPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessEditorialPDF/EPUBAccelerated Decline of Aerobic Fitness With Healthy AgingWhat Is the Good News? Philip A. Ades, MD and Michael J. Toth, PhD Philip A. AdesPhilip A. Ades From the University of Vermont College of Medicine, Burlington. and Michael J. TothMichael J. Toth From the University of Vermont College of Medicine, Burlington. Originally published2 Aug 2005https://doi.org/10.1161/CIRCULATIONAHA.105.553321Circulation. 2005;112:624–626As we get older, even if we are healthy, we become less fit. At the extreme, we become disabled and eventually die. Although this deterioration in physical work capacity is widely accepted, few studies have characterized changes in aerobic capacity across the age span. Instead, the majority of studies have utilized cross-sectional designs. These studies are limited, however, by selective survival—ie, older participants, as a group, are inherently healthier than younger individuals, as evidenced by their survival. Thus, the 5% to 10% drop in aerobic fitness per decade, defined from cross-sectional studies, may well be an underestimate.1–6See p 674The Baltimore Longitudinal Study of AgingThe Baltimore Longitudinal Study of Aging began recruiting healthy individuals into a long-term descriptive study in 1978.7 Subjects were screened at baseline for clinical heart disease. Screening included a symptom-limited exercise test supplemented by nuclear perfusion imaging in men >40 and women >50 years of age. The participants were predominantly white and college educated and lived in the Baltimore-Washington metropolitan area. Every 2 years they spent 2 full days at the Gerontology Research Center in Baltimore, Md, where they underwent medical, physiological, and psychological testing. Individuals without onset of clinical heart disease underwent maximal treadmill exercise testing on alternate visits. It should be noted that although elimination of individuals who developed clinical heart disease allowed the researchers to examine the effects of aging per se on exercise capacity without the confounding effects of disease, this approach almost certainly removed less-fit individuals from the analysis because poor fitness is a well-known cardiac risk factor. A total of 3379 exercise tests were performed in this study, all consistently supervised by the same cardiologist (Dr Fleg). Another 10% of tests were excluded because of failure to attain 85% of the maximal predicted heart rate or because the tester deemed a test to be nonmaximal on the basis of direct observation. Finally, another 3% were excluded for individuals who were taking a β-adrenergic–blocking medication. One could question whether the individuals with chronotropic incompetence or inability to attain 85% of the maximal age-predicted heart rate should have been excluded if they otherwise performed a maximal test, verified by the attainment of a respiratory exchange ratio >1.00, as these simply may have reflected the tail of the bell-shaped maximal heart rate curve. It is possible that this factor, again, excluded the least fit individuals.The resulting dataset represents the most comprehensive examination of longitudinal changes in aerobic fitness throughout the aging spectrum in healthy individuals. By clustering repeated exercise test data within 6 age decades, a rate of decline within successive decades is calculated. Thus, the selection biases inherent in cross-sectional studies—in particular, the fact that older participants, by dint of their survival, are generally healthier than younger participants overall—are avoided. Fleg and coworkers7 show that the previously defined linear decline of aerobic capacity of 5% to 10% per decade is indeed incorrect, particularly in the later decades of life. Most importantly, these data suggest that the age-related decrease in aerobic capacity is nonlinear, increasing progressively each decade. For example, whereas the decline in peak V̇o2 was 3% to 6% in the third and fourth decades, it was far greater, >20% per decade, after age 70. The accelerated decline persisted even when the data were adjusted by fat-free mass, which also declines with age. Although it is possible that the effect of fat-free mass on peak V̇o2 was not entirely corrected for by calculating a simple ratio of peak V̇o2 (mL/min) divided by fat-free mass,8 it is unlikely that loss of muscle mass alone accounts for the accelerated decline in fitness given the pattern of age-related changes in fat-free mass. Reduced peak V̇o2 was found in all physical activity quartiles. It should not be overlooked, however, that more physically active individuals had higher peak V̇o2 measures than less active individuals at all ages. From a physiological perspective, these results suggest that the loss of aerobic fitness with age is not attributable to the erosion of muscle mass or to physical inactivity. Instead, changes that alter the delivery of oxygen to exercising muscles or the ability of muscles to utilize oxygen are more likely determinants of declining aerobic fitness. If this is the case, age-related changes in muscle perfusion or oxidative capacity may lie at the root of diminished aerobic exercise capacity in the elderly. In support of an effect of age on muscle oxidative capacity, recent findings show that aging is associated with impaired skeletal muscle mitochondrial function secondary to mitochondrial DNA oxidative damage and loss.9Fitness Declines Precipitously in Late Middle Age: Bad News?Because the logical end point of declining exercise capacity, at its extreme, is death, one can question whether these data are also relevant to overall mortality. Similarly, one can also question if, as Fleg et al7 suggest, the presented data are relevant to an accelerated development of functional disability. Do individuals have no ability to alter structure, function, or clinical outcome by exercise or other lifestyle habits? Should all who pass the age of 40 passively resign themselves to a fast track to physical disability?With regard to the implications of these data on mortality, I am reminded of the treatise of baseball statistician Bill James relating the peak of a player's hitting ability to the length of his career in the Major Leagues.10 The higher the peak of the parabolic curve of hitting ability versus age, the broader the parabola as it crosses the x-axis (in years), the longer the stay in the Major Leagues. Although the data of Fleg et al7 support the concept that whatever the aerobic fitness level, whatever the physical activity level, there is a sharper decline over time after age 60 or 70 than before, they do not deny data from several sources that relate peak aerobic capacity and physical activity in middle-aged adults to increased longevity11–13 and delayed disability.14,15 Again, a higher peak yields a broader parabola with increased longevity. Furthermore, if you accept the concept that some physical dysfunction will generally precede death (absent a sudden death), it is in fact preferable for the graph of the decline to have a shelf with maintained aerobic capacity, until an accelerating late drop, as opposed to a more protracted, linear deterioration.A separate though relatively minor concern with these fitness data from the Baltimore Longitudinal Study of Aging is that of the healthy cohort effect.16 This suggests that individuals who volunteer for health-related research studies are often more fit and health oriented than the population as a whole. In the study of Vita et al,14 several lifestyle factors, including exercise patterns, body mass index, and smoking, were closely related to end-of-life disability patterns. Not only was the onset of disability delayed by up to 5 years in the lowest-risk group (those who were thin, did not smoke, and exercised), but it was also noted that these same factors led to a compacting of end-of-life disability. If indeed the data of Fleg et al7 are skewed by such healthier volunteers, along with the elimination of individuals who did not attain 85% of their maximal predicted heart rate and individuals who developed heart disease, we may be observing such an effect. Rebutting this, at least in part, would be their finding that even their least fit individuals also saw a decline in fitness in their 70s.Fitness Versus DisabilityWhether this decline in aerobic fitness leads to functional disability is not as clear as implied. Disability is a complex construct that includes not only aerobic capacity, which in practical terms is reflected by walking capacity, but also strength, balance, coordination, and psychological factors.17,18 Perhaps the best-studied biological correlate of physical function outside of aerobic fitness is muscle strength. Muscle strength has been shown to be at least as important a determinant of functional capacity as endurance in healthy and diseased elderly persons,19–21 and strength training can improve performance of walking, climbing stairs, carrying groceries, and other household activities without altering aerobic capacity.22–24 This implies that the very activity of lifting the leg while walking, a trivial detail in the young, is a limiting factor to walking endurance in the elderly. Caution should be taken, however, in imparting too much importance to biological factors alone. As much as functional capacity is limited by physiological capacity, it is undoubtedly dependent on psychological factors. For instance, recent work from our laboratory showed that mental depression was an equally important determinant of self-reported disability as was aerobic fitness in older patients with heart disease.17 These findings do not, of course, deny the findings of Fleg et al,7 but raise the question of whether the drop in aerobic capacity translates into a proportional drop in physical functional performance. For instance, Posner et al25 showed that the ability to perform activities of daily living was not dependent on aerobic fitness until peak V̇o2 dropped below ≈750 mL/min. Thus, although erosion of peak V̇o2 with age undoubtedly accompanies the development of disability, its overall contribution to the reduced capacity to perform normal daily activities is unclear.ConclusionsThe important article by Fleg and colleagues presents a comprehensive examination of longitudinal changes in aerobic fitness through the aging spectrum in healthy individuals. The foresight and energy of the investigators are laudable, as such a dataset could not have been assembled without persistence and focus. A particular strength is the collection of repeated-measures longitudinal data, which avoids the biases of cross-sectional studies. A decline in aerobic fitness was noted after age 40, which accelerates as individuals enter their sixth and seventh decades. This decline is independent of muscle mass and physical activity levels. Thus, the bad news is that your aerobic fitness will decline with age no matter what you do. The good news is that individuals who start with higher aerobic capacity and continue their activity habits throughout life maintain a greater fitness level at all points in the aging spectrum. In light of the relationship between aerobic fitness and mortality,11–13 this suggests that performance of regular exercise throughout the lifespan will both lengthen life and postpone and compact end-of-life disability.13,14The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.Dr Ades is supported in part by grants NHLBI 9 RO1-HL72851-04A1, R01 HL73351-01A1, and MO1RR00109. Dr Toth is supported by grants AR-02125 and AG-021602. The authors thank Patrick Savage, MS, for reviewing this manuscript.FootnotesCorrespondence to Philip A. Ades, MD, McClure 1, Cardiology, University of Vermont College of Medicine, Fletcher-Allen Health Care, Burlington, VT 05401. E-mail [email protected] References 1 Astrand I. Aerobic work capacity in men and women with special reference to age. Acta Physiol Scand. 1960; 169 (suppl): 1–92.Google Scholar2 Fleg JL, Lakatta EG. Role of muscle loss in the age-associated reduction in peak VO2max. J Appl Physiol. 1988; 65: 1147–1151.CrossrefMedlineGoogle Scholar3 Jackson AS, Beard EF, Wier LT, Ross RM, Stuleville JE, Blair SW. Changes in aerobic power of men ages 25–70 yr. Med Sci Sports Exerc. 1995; 27: 113–120.MedlineGoogle Scholar4 Ogawa TR, Spina R, Martin WH, Kohrt WM, Schechtmen KB, Holloszy JP, Ehsani AA. Effects of aging, sex and physical training on cardiovascular response to exercise. Circulation. 1992; 86: 494–503.CrossrefMedlineGoogle Scholar5 Fitzgerald MD, Tanaka H, Iran ZV, Seals DR. Age-related declines in maximal aerobic capacity in regularly exercising vs sedentary women: a meta-analysis. J Appl Physiol. 1997; 83: 160–165.CrossrefMedlineGoogle Scholar6 Toth MJ, Gardner AW, Ades PA, Poehlman ET. Contribution of body composition and physical activity to age-related decline in peak VO2 in men and women. J Appl Physiol. 1994; 77: 647–652.CrossrefMedlineGoogle Scholar7 Fleg JL, Morrell CH, Bos AG, Brant LJ, Talbot LA, Wright JG, Lakatta EG. Accelerated longitudinal decline of aerobic capacity in healthy older adults. Circulation. 2005; 112: 674–682.LinkGoogle Scholar8 Toth MJ, Goran MI, Ades PA, Howard DB, Poehlman ET. Examination of data normalization procedures for expressing peak VO2 data. J Appl Physiol. 1993; 75: 2288–2292.CrossrefMedlineGoogle Scholar9 Short KR, Bigelow ML, Kahl J, Singh R, Coenen-Schimke J, Raghavakaimal S, Nair KS. Decline in skeletal muscle mitochondrial function with aging in humans. Proc Natl Acad Sci U S A. 2005; 102: 5618–5623.CrossrefMedlineGoogle Scholar10 James B. Looking for the prime. In: Bill James Baseball Abstract. New York, NY: Ballantine; 1982: 191–206.Google Scholar11 Blair SN, Kampert JB, Kohl HW 3rd, Barlow CE, Macera CA, Paffenbarger RS Jr, Gibbons LW. Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women. JAMA. 1996; 276: 205–210.CrossrefMedlineGoogle Scholar12 Wei M, Kampert JB, Barlow CE, Nichaman MZ, Gibbons LW, Paffenbarger RS Jr, Blair SN. Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. JAMA. 1999; 282: 1547–1553.CrossrefMedlineGoogle Scholar13 Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002; 346: 793–801.CrossrefMedlineGoogle Scholar14 Vita AJ, Terry RB, Hubert HB, Fries JF. Aging, health risks, and cumulative disability. N Engl J Med. 1998; 338: 1035–1041.CrossrefMedlineGoogle Scholar15 Wang BW, Ramey DR, Schettler JD, Hubert HB, Fries JF. Postponed development of disability in elderly runners: a 13-year longitudinal study. Arch Intern Med. 2002; 162: 2285–2294.CrossrefMedlineGoogle Scholar16 Posthuma WF, Westendorp RG, Vandenbroucke JP. Cardioprotective effect of hormone replacement therapy in postmenopausal women: is the evidence biased? BMJ. 1994; 308: 1268–1269.CrossrefMedlineGoogle Scholar17 Ades PA, Savage PD, Tischler MD, Poehlman ET, Dee J, Niggel J. Determinants of disability in older coronary patients. Am Heart J. 2002; 143: 151–156.CrossrefMedlineGoogle Scholar18 Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdeiner J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA. Frailty in older adults: evidence for a phenotype. J Geront: Med Sci. 2001; 56A: M146–M156.Google Scholar19 Foldvari M, Clark M, Laviolette LC, Bernstein MA, Kaliton D, Castaneda C, Pu CT, Hausdorff JM, Fielding RA, Fiatarone-Singh MA. Association of muscle power with functional status in community-dwelling elderly women. J Gerontol. 2000; 55: M192–M199.CrossrefGoogle Scholar20 Neill WA, Branch LG, and DeJong G. Cardiac disability—the impact of coronary disease on patients' daily activities. Arch Intern Med. 1981; 145: 1642–1647.Google Scholar21 Hendrican MC, McKelvie RS, Smith T, McCartney N, Pogue J, Teo KK, Yusuf S. Functional capacity in patients with congestive heart failure. J Cardiac Fail. 2000; 6: 214–219.CrossrefMedlineGoogle Scholar22 Ades PA, Ballor DL, Ashikaga T, Utton JL, Nair KS. Weight training improves walking endurance in healthy elderly persons. Ann Intern Med. 1996; 15; 124: 568–572.Google Scholar23 Brochu M, Savage P, Lee M, Dee J, Cress ME, Poehlman ET, Tischler M, Ades PA. Effects of resistance training on physical function in older disabled women with coronary heart disease. J Appl Physiol. 2002; 92: 672–678.MedlineGoogle Scholar24 Ades PA, Savage PD, Cress ME, Brochu M, Lee NM, Poehlman ET. Resistance training on physical performance in disabled older female cardiac patients. Med Sci Sports Exerc. 2003; 35: 1265–1270.CrossrefMedlineGoogle Scholar25 Posner JD, McCully KK, Landsber LA, Sands LP, Tycenski P, Hofmann MT, Wetterholdt KL, Shaw CE. Physical determinants of independence in mature women. Arch Phys Med Rehab. 1995; 76: 373–380.CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsCited By Goncin N, Linares A, Lloyd M and Dogra S (2020) Does sedentary time increase in older adults in the days following participation in intense exercise?, Aging Clinical and Experimental Research, 10.1007/s40520-020-01502-6, 32:12, (2517-2527), Online publication date: 1-Dec-2020. Licker M and Navarro R (2020) Prehabilitation in Thoracic Surgery Anesthesia in Thoracic Surgery, 10.1007/978-3-030-28528-9_3, (33-47), . Castle P, Scheven U, Crouch A, Cao A, Goergen C and Greve J (2018) Anatomical location, sex, and age influence murine arterial circumferential cyclic strain before and during dobutamine infusion, Journal of Magnetic Resonance Imaging, 10.1002/jmri.26232, 49:1, (69-80), Online publication date: 1-Jan-2019. Lu Z, Woo J and Kwok T (2017) The Effect of Physical Activity and Cardiorespiratory Fitness on All-Cause Mortality in Hong Kong Chinese Older Adults, The Journals of Gerontology: Series A, 10.1093/gerona/glx180, 73:8, (1132-1137), Online publication date: 9-Jul-2018. Rosado-Pérez J and Mendoza-Núñez V (2018) Relationship Between Aerobic Capacity With Oxidative Stress and Inflammation Biomarkers in the Blood of Older Mexican Urban-Dwelling Population, Dose-Response, 10.1177/1559325818773000, 16:2, (155932581877300), Online publication date: 1-Apr-2018. Dulac M, Carvalho L and Aubertin-Leheudre M (2018) Functional capacity depends on lower limb muscle strength rather than on abdominal obesity in active postmenopausal women, Menopause, 10.1097/GME.0000000000000970, 25:2, (176-181), Online publication date: 1-Feb-2018. Van Oort C, Jackowski S, Eisenmann J, Sherar L, Bailey D, Mirwald R and Baxter-Jones A (2013) Tracking of aerobic fitness from adolescence to mid-adulthood, Annals of Human Biology, 10.3109/03014460.2013.817606, 40:6, (547-553), Online publication date: 1-Nov-2013. McNarry M and Lewis M (2012) Interaction between age and aerobic fitness in determining heart rate dynamics, Physiological Measurement, 10.1088/0967-3334/33/6/901, 33:6, (901-914), Online publication date: 1-Jun-2012. McNarry M, Kingsley M and Lewis M (2012) Influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 10.1152/ajpregu.00203.2012, 303:8, (R791-R798), Online publication date: 15-Oct-2012. Yu R, Yau F, Ho S and Woo J (2011) Cardiorespiratory fitness and its association with body composition and physical activity in Hong Kong Chinese women aged from 55 to 94 years, Maturitas, 10.1016/j.maturitas.2011.05.003, 69:4, (348-353), Online publication date: 1-Aug-2011. Aragão F, Abrantes C, Gabriel R, Sousa M, Castelo-Branco C and Moreira M (2011) Effects of body composition and menopause characteristics on maximal oxygen uptake of postmenopausal women, Menopause, 10.1097/gme.0b013e31821b00b0, 18:11, (1191-1197), Online publication date: 1-Nov-2011. Krause M, Januário R, Hallage T, Haile L, Miculis C, Gama M, Goss F and da Silva S A Comparison of Functional Fitness of Older Brazilian and American Women, Journal of Aging and Physical Activity, 10.1123/japa.17.4.387, 17:4, (387-397) WELSCH M, DOBROSIELSKI D, ARCE-ESQUIVEL A, WOOD R, RAVUSSIN E, ROWLEY C and JAZWINSKI S (2008) The Association between Flow-Mediated Dilation and Physical Function in Older Men, Medicine & Science in Sports & Exercise, 10.1249/MSS.0b013e31816c5552, 40:7, (1237-1243), Online publication date: 1-Jul-2008. Amandels S, Schepers D, Pennemans V and Vanhees L (2008) 8 Cardiovasculaire revalidatie en de vergrijzing: dienen we onze doelstellingen aan te passen? Jaarboek Fysiotherapie kinesitherapie 2008, 10.1007/978-90-313-9490-6_8, (122-134), . Kenny G, Yardley J, Martineau L and Jay O (2008) Physical work capacity in older adults: Implications for the aging worker, American Journal of Industrial Medicine, 10.1002/ajim.20600, 51:8, (610-625), Online publication date: 1-Aug-2008. Fontaine G, Lacotte J, Hidden-Lucet F and Frank R Catheter Ablation of Ventricular Tachycardia Arrhythmogenic RV Cardiomyopathy/Dysplasia, 10.1007/978-88-470-0490-0_20, (181-188) Price S, Wiecha S, Cieśliński I, Śliż D, Kasiak P, Lach J, Gruba G, Kowalski T and Mamcarz A (2022) Differences between Treadmill and Cycle Ergometer Cardiopulmonary Exercise Testing Results in Triathletes and Their Association with Body Composition and Body Mass Index, International Journal of Environmental Research and Public Health, 10.3390/ijerph19063557, 19:6, (3557) August 2, 2005Vol 112, Issue 5 Advertisement Article InformationMetrics https://doi.org/10.1161/CIRCULATIONAHA.105.553321PMID: 16061752 Originally publishedAugust 2, 2005 KeywordsEditorialsexerciseagingphysiologyPDF download Advertisement SubjectsExercise TestingRehabilitation
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