Clinical Application of the 70-Gene Profile: The MINDACT Trial
2008; Lippincott Williams & Wilkins; Volume: 26; Issue: 5 Linguagem: Inglês
10.1200/jco.2007.14.3222
ISSN1527-7755
AutoresFátima Cardoso, Laura van’t Veer, Emiel J. Rutgers, Sherene Loi, Stella Mook, Martine Piccart,
Tópico(s)Cancer Genomics and Diagnostics
ResumoThe 70-gene profile is a new prognostic tool that has the potential to greatly improve risk assessment and treatment decision making for early breast cancer. Its prospective validation is currently ongoing through the MINDACT (Microarray in Node-Negative Disease May Avoid Chemotherapy) trial, a 6,000-patient randomized, multicentric trial. This article reviews the several steps in the development of the profile from its discovery to its clinical validation.
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