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The Cycloaddition Strategy for the Synthesis of Natural Products Containing Carbocyclic Seven‐Membered Rings

2006; Wiley; Volume: 12; Issue: 13 Linguagem: Inglês

10.1002/chem.200501083

1521-3765

Merle A. Battiste, Phillip M. Pelphrey, Dennis L. Wright,

Oxidative Organic Chemistry Reactions

Highly substituted carbocyclic seven-membered rings are frequently found in natural products and their synthesis represents a significant challenge to the synthetic chemist. Direct intramolecular cyclization of these systems often proves difficult and this fact has catalyzed the development of a variety of strategies based on a convergent intermolecular cycloaddition strategy. This concept article discusses the major cycloaddition approaches utilized to access these types of structures and primarily focuses on examples employed in the synthesis of natural products.