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Clinical relevance of the host responses of periodontitis

2007; Wiley; Volume: 43; Issue: 1 Linguagem: Inglês

10.1111/j.1600-0757.2006.00169.x

1600-0757

Denis F. Kinane, P. Mark Bartold,

HIV/AIDS oral health manifestations

Periodontology 2000Volume 43, Issue 1 p. 278-293 Clinical relevance of the host responses of periodontitis Denis F. Kinane, Denis F. KinaneSearch for more papers by this authorP. Mark Bartold, P. Mark BartoldSearch for more papers by this author Denis F. Kinane, Denis F. KinaneSearch for more papers by this authorP. Mark Bartold, P. Mark BartoldSearch for more papers by this author First published: 04 January 2007 https://doi.org/10.1111/j.1600-0757.2006.00169.xCitations: 121Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Aas E. Hyperplasia gingivae diphenylhydantoinea. A clinical, histological and biochemical study. Acta Odontol Scand 1963: S34: 1–142. 2 Abe M, Tominaga K, Wakasa H. Characterization of human B-lymphocyte subpopulations, particularly human CD5+ B-lymphocyte subpopulation within the mantle zones of secondary follicles. Leukemia 1994: 8: 1039–1044. 3 Aldridge JP, Lester V, Watts TL, Collins A, Viberti G, Wilson RF. Single-blind studies of the effects of improved periodontal health on metabolic control in type 1 diabetes mellitus. J Clin Periodontol 1995: 22: 271–275. 4 Anderson HH, Rapley JW, Williams DR. Gingival overgrowth with valproic acid: a case report. Gingival overgrowth with valproic acid: a case report. ASDC J Dent Child 1997: 64: 294–297. 5 Aoyagi T, Sugawara-Aoyagi M, Yamazaki K, Hara K. Interleukin 4 (IL-4) and IL-6-producing memory T-cells in peripheral blood and gingival tissue in periodontitis patients with high serum antibody titers to Porphyromonas gingivalis. Oral Microbiol Immunol 1995: 10: 304–310. 6 Axtelius B, Soderfeldt B, Nilsson A, Edwardsson S, Attstrom R. Therapy-resistant periodontitis. Psychosocial characteristics. Therapy-resistant periodontitis. Psychosocial characteristics. J Clin Periodontol 1998: 25: 428–491. 7 Baker JJ, Tondreau SP. The stimulation of human peripheral blood lymphocytes by oral bacteria: macrophage and T-cell dependence. J Dent Res 1985: 64: 906–912. 8 Barr C, Lopez MR, Rua-Dobles A. Periodontal changes by HIV serostatus in a cohort of homosexual and bisexual men. J Clin Periodontol 1992: 19: 794–801. 9 Bartold PM, Narayanan AS. Biology of Periodontal Connective Tissue. Chicago, IL: Quintessence Publications, Inc., 1998. 10 Bartold PM, Kylstra A, Lawson R. Substance P: an immunohistochemical and biochemical study in human gingival tissues. A role for neurogenic inflammation? J Periodontol 1994: 65: 1113–1121. 11 Beck JD, Cusmano L, Green-Helms W, Koch GG, Offenbacher S. A 5-year study of attachment loss in community-dwelling older adults: incidence density. J Periodontal Res 1997: 32: 506–515. 12 Bennett JA, Christian JM. Cyclosporine-induced gingival hyperplasia: case report and literature review. J Am Dent Assoc 1985: 111: 272–273. 13 Bird AG, Britton S. A new approach to the study of human B lymphocyte function using an indirect plaque assay and a direct B cell activator. Immunol Rev 1979: 45: 41–67. 14 Birkedal-Hansen H. Role of matrix metalloproteinases in human periodontal diseases. J Periodontol 1993: 64: 474–484. 15 Bolin A, Lavstedt S, Frithiof L, Henrikson CO. Proximal alveolar bone loss in a longitudinal radiographic investigation. IV. Smoking and some other factors influencing the progress in individuals with at least 20 remaining teeth. Acta Odontol Scand 1986: 44: 263–269. 16 Brandtzaeg P. Local factors of resistance in the gingival area. J Periodontal Res 1966: 1: 19–42. 17 Bullon P, Machuca G, Martinez Sahuquillo A, Rojas J, Lacalle JR, Rios JV, Velasco E. Clinical assessment of gingival size among patients treated with diltiazem. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995: 79: 300–304. 18 Burkett LW. Oral Medicine Diagnosis and Treatment, 6th edn. Philadelphia, PA: J.B. Lippincott, 1972: 273–282. 19 Carlos JP, Wolfe MD, Zambon JJ, Kingman A. Periodontal disease in adolescents: some clinical and microbiologic correlates of attachment loss. J Dent Res 1988: 67: 1510–1514. 20 Cohen DW, Shapiro J, Friedman L, Kyle GC, Franklin S. A longitudinal investigation of the periodontal changes during pregnancy and fifteen months post-partum. II. J Periodontol 1971: 42: 653–657. 21 Cohen-Cole SA, Cogen RB, Stevens AW Jr, Kirk K, Gaitan E, Bird J, Cooksey R, Freeman A. Psychiatric, psychosocial, and endocrine correlates of acute necrotizing ulcerative gingivitis (trench mouth): a preliminary report. Psychiatr Med 1983: 1: 215–225. 22 Croucher R, Marcenes WS, Torres MC, Hughes F, Sheiham A. The relationship between life-events and periodontitis. A case–control study. J Clin Periodontol 1997: 24: 39–43. 23 Danks JA, McHale JC, Clark SP, Chou ST, Scurry JP, Ingleton PM, Martin TJ. In situ hybridization of parathyroid hormone-related protein in normal skin, skin tumors, and gynecological cancers using digoxigenin-labeled probes and antibody enhancement. J Histochem Cytochem 1995: 43: 5–10. 24 De Vries WR, Bernards NT, De Rooij MH, Koppeschaar HP. Dynamic exercise discloses different time-related responses in stress hormones. Psychosom Med 2000: 62: 866–872. 25 Dummett CO. Dentistry contributes to regional health planning by sponsoring its first public health institute in the South. J Natl Med Assoc 1954: 46: 168–171. 26 Ellis JS, Seymour RA, Steele JG, Robertson P, Butler TJ, Thomason JM. Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study. J Periodontol 1999: 70: 63–67. 27 Engebretson SP, Grbic JT, Singer R, Lamster IB. GCF IL-1beta profiles in periodontal disease. J Clin Periodontol 2002: 29: 48–53. 28 Enwonwu CO. Epidemiological and biochemical studies of necrotizing ulcerative gingivitis and noma (cancrum oris) in Nigerian children. Arch Oral Biol 1972: 17: 1357–1371. 29 Fujihashi K, Beagley KW, Kono Y, Aicher WK, Yamamoto M, DiFabio S, Xu-Amano J, McGhee JR, Kiyono H. Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4. Am J Pathol 1993: 142: 1239–1250. 30 Garrison SW, Nichols FC. LPS-elicited secretory responses in monocytes: altered release of PGE2 but not IL-1 beta in patients with adult periodontitis. J Periodontal Res 1989: 24: 88–95. 31 Gemmell E, Seymour GJ. Gamma delta T lymphocytes in human periodontal disease tissue. J Periodontol 1995: 66: 780–785. 32 Genco RJ, Zambon JJ, Christersson LA. The origin of periodontal infections. Adv Dent Res 1988: 2: 245–259. 33 Genco RJ, Ho AW, Kopman J, Grossi SG, Dunford RG, Tedesco LA. Models to evaluate the role of stress in periodontal disease. Ann Periodontol 1998: 3: 288–302. 34 Giannobile WV, Lee CS, Tomala MP, Tejeda KM, Zhu Z. Platelet-derived growth factor (PDGF) gene delivery for application in periodontal tissue engineering. J Periodontol 2001: 72: 815–823. 35 Goldhaber P, Giddon DB. Acute necrotising ulcerative gingivitis: a study of some contributing factors and their validity in an army population. Int Dent J 1964: 1964: 346–358. 36 Goodson JJ, Plays MD, Socransky SS. Gingival bleeding accentuated by plaque in healthy IL-1(+) genotype subjects. J Clin Periodontol 2000: 31: 229–238. 37 Green LW, Tryon WW, Marks B, Huryn J. Periodontal disease as a function of life events stress. J Human Stress 1986: 12: 32–36. 38 Grossi SG, Zambon JJ, Ho AW, Koch G, Dunford RG, Machtei EE, Norderyd OM, Genco RJ. Assessment of risk for periodontal disease. I. Risk indicators for attachment loss. J Periodontol 1994: 65: 260–267. 39 Haapasalmi K, Makela M, Oksala O, Heino J, Yamada KM, Uitto VJ, Larjava H. Expression of epithelial adhesion proteins and integrins in chronic inflammation. Am J Pathol 1995: 147: 193–206. 40 Hassell T, O'Donnell J, Pearlman J, Tesini D, Murphy T, Best H. Phenytoin induced gingival overgrowth in institutionalized epileptics. J Clin Periodontol 1984: 11: 242–253. 41 Holm-Pedersen P, Loe H. Flow of gingival exudate as related to menstruation and pregnancy. J Periodontal Res 1967: 2: 13–20. 42 Ito H, Harada Y, Matsuo T, Ebisu S, Okada H. Possible role of T cells in the establishment of IgG plasma cell-rich periodontal lesion – augmentation of IgG synthesis in the polyclonal B cell activation response by autoreactive T cells. J Periodontal Res 1988: 23: 39–45. 43 Jette AM, Feldman HA, Tennstedt SL. Tobacco use: a modifiable risk factor for dental disease among the elderly. Am J Public Health 1993: 83: 1271–1276. 44 Jin QM, Anusaksathien O, Webb SA, Rutherford RB, Giannobile WV. Gene therapy of bone morphogenetic protein for periodontal tissue engineering. J Periodontol 2003: 74: 202–213. 45 Johannessen AC, Nilsen R, Knudsen GE, Kristoffersen T. In situ characterization of mononuclear cells in human chronic marginal periodontitis using monoclonal antibodies. J Periodontal Res 1986: 21: 113–127. 46 Kalkwarf KL. Effect of oral contraceptive therapy on gingival inflammation in humans. J Periodontol 1978: 49: 560–563. 47 Kapur RN, Girgis S, Little TM, Masotti RE. Diphenylhydantoin-induced gingival hyperplasia: its relationship to dose and serum level. Dev Med Child Neurol 1973: 15: 483–487. 48 Katz J, Givol N, Chaushu G, Taicher S, Shemer J. Vigabatrin-induced gingival overgrowth. J Clin Periodontol 1997: 24: 180–182. 49 Kinane DF, Attstrom R. Advances in the pathogenesis of periodontitis. Group B consensus report of the fifth European Workshop in Periodontology. J Clin Periodontol 2005: 32 (Suppl. 6), 130–131. 50 Kinane DF, Chestnutt IG. Relationship of diabetes to periodontitis. Curr Opin Periodontol 1997: 4: 29–34. 51 Kinane DF, Hart TC. Genes and gene polymorphisms associated with periodontal disease. Crit Rev Oral Biol Med 2003: 14: 430–449. 52 Kirkham J, Robinson C, Smith AJ, Spence JA. The effect of periodontal disease on sulphated glycosylaminoglycan distribution in the sheep periodontium. Arch Oral Biol 1992: 37: 1031–1037. 53 Klar LA. Gingival hyperplasia during dilantin-therapy; a survey of 312 patients. J Public Health Dent 1973: 33: 180–185. 54 Kofoed JA, Bozzini CE. The effect of hydrocortisone on the concentration and synthesis of acid mucopolysaccharides in the rat gingiva. J Periodontal Res 1970: 5: 259–262. 55 Lappin DF, Koulouri O, Radvar M, Hodge P, Kinane DF. Relative proportions of mononuclear cell types in periodontal lesions analyzed by immunohistochemistry. J Clin Periodontol 1999: 26: 183–189. 56 Lappin DF, MacLeod CP, Kerr A, Mitchell T, Kinane DF. Anti-inflammatory cytokine IL-10 and T cell cytokine profile in periodontitis granulation tissue. Clin Exp Immunol 2001: 123: 294–300. 57 Last JA. A dictionary of epidemiology. Int J Epidemiology 1982: 11: 188–184. 58 Lee HM, Ciancio SG Tuter G, Ryan ME, Komaroff E, Golub LM. Subantimicrobial dose doxycycline efficacy as a matrix metalloproteinase inhibitor in chronic periodontitis patients is enhanced when combined with a non-steroidal anti-inflammatory drug. J Periodontol 2004: 75: 453–463. 59 Lindhe J, Attsfrom R. Gingival exudation during the menstrual cycle. J Periodontal Res 1967: 2: 194–198. 60 Lindhe J, Haffajee AD, Socransky SS. Progression of periodontal disease in adult subjects in the absence of periodontal therapy. J Clin Periodontol 1983: 10: 433–442. 61 Lipari WA, Blake LC, Zipkin I. Preferential response of the periodontal apparatus and the epiphyseal plate to hydrocortisone and fluoride in the rat. J Periodontol 1974: 45: 879–890. 62 Loe H. Periodontal disease. The sixth complication of diabetes mellitus. Diabetes Care 1993: 16: 329–334. 63 Loee H. Periodontal changes in pregnancy. J Periodontol 1965: 36: 209–217. 64 Loee H, Theilade E, Jensen SB. Experimental gingivitis in man. J Periodontol 1965: 36: 177–187. 65 Longhurst P, Gillett R, Johnson NW. Electron microscope quantitation of inflammatory infiltrates in childhood gingivits. J Periodontal Res 1980: 15: 255–266. 66 Lundqvist C, Baranov V, Teglund S, Hammarstrom S, Hammarstrom ML. Cytokine profile and ultrastructure of intraepithelial gamma delta T cells in chronically inflamed human gingiva suggest a cytotoxic effector function. J Immunol 1994: 153: 2302–2312. 67 MacDonald TT. Effector and regulatory lymphoid cells and cytokines in mucosal sites. Curr Top Microbiol Immunol 1999: 236: 113–135. 68 Machtei EE, Dunford R, Hausmann E, Grossi SG, Powell J, Cummins D, Zambon JJ, Genco RJ. Longitudinal study of prognostic factors in established periodontitis patients. J Clin Periodontol 1997: 24: 102–109. 69 Mackler BF, Waldrop TC, Schur P, Robertson PB, Levy BM. IgG subclasses in human periodontal disease. I. Distribution and incidence of IgG subclass bearing lymphocytes and plasma cells. J Periodontal Res 1978: 13: 109–119. 70 Manhart SS, Reinhardt RA, Payne JB, Seymour GJ, Gemmell E, Dyer JK, Petro TM. Gingival cell IL-2 and IL-4 in early-onset periodontitis. J Periodontol 1994: 65: 807–813. 71 Maupin CC, Bell WB. The relationship of 17-hydroxycorticosteroid to acute necrotizing ulcerative gingivitis. J Periodontol 1975: 46: 721–722. 72 Meng HX, Zheng LF. T cells and T-cell subsets in periodontal diseases. J Periodontal Res 1989: 24: 121–126. 73 Michalowicz BS, Diehl SR, Gunsolley JC, Sparks BS, Brooks CN, Koertge TE, Califano JV, Burmeister JA, Schenkein HA. Evidence of a substantial genetic basis for risk of adult periodontitis. J Periodontol 2000: 71: 1699–1707. 74 Moss ME, Beck JD, Kaplan BH, Offenbacher S, Weintraub JA, Koch GG, Genco RJ, Machtei EE, Tedesco LA. Exploratory case–control analysis of psychosocial factors and adult periodontitis. J Periodontol 1996: 67: 1060–1069. 75 Nagase HJ, Enghild K, Suzuki K, Slavasen G. Activation of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and 4-Aminophenyl) mercuric acetate. Biochemistry 1990: 29: 5783–5789. 76 Narayanan AS, Engel LD, Page RC. The effect of chronic inflammation on the composition of collagen types in human connective tissue. Coll Relat Res 1983: 3: 323–334. 77 Ojanotko A, Harri MP. Progesterone metabolism by rat oral mucosa. II. The effect of pregnancy. J Periodontal Res 1982: 17: 196–201. 78 Okada H, Kida T, Yamagami H. Identification and distribution of immunocompetent cells in inflamed gingiva of human chronic periodontitis. Infect Immun 1983: 41: 365–374. 79 Okada H, Ito H, Harada Y. T-cell requirement for establishment of the IgG-dominant B-cell lesion in periodontitis. J Periodontal Res 1987: 22: 187–189. 80 Oliver RC, Tervonen T. Diabetes – a risk factor for periodontitis in adults? J Periodontol 1994: 65: 530–538. 81 Overall CM, Wrana JL, Sodek J. Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression. J Biol Chem 1991: 25: 14064–14071. 82 Page RC, Schroeder HE. Pathogenesis of inflammatory periodontal disease. A summary of current work. Lab Invest 1976: 34: 235–249. 83 Page RC, Sims TJ, Geissler F, Altman LC, Baab DA. Defective neutrophil and monocyte motility in patients with early onset periodontitis. Infect Immun 1985: 47: 169–175. 84 Papapanou PN, Wennstrom JL, Grondahl K. Periodontal status in relation to age and tooth type. A cross-sectional radiographic study. J Clin Periodontol 1988: 15: 469–478. 85 Paster BJ, Dewhirst FE. Phylogenetic foundation of spirochetes. J Mol Microbiol Biotechnol 2000: 2: 341–344. 86 Rees TD. The diabetic dental patient. Dent Clin North Am 1994: 38: 447–463. 87 Reinhardt RA, McDonald TL, Bolton RW, DuBois LM, Feely DE, Kaldahl WB. In situ activated T lymphocytes in active versus stable periodontal lesions. J Periodontal Res 1988: 23: 295–302. 88 Reinhardt RA, Bolton RW, McDonald TL, DuBois LM, Kaldahl WB. In situ lymphocyte subpopulations from active versus stable periodontal sites. J Periodontol 1988: 59: 656–670. 89 Reynolds JJ. Collagenases and tissue inhibitors of metalloproteinases: a functional balance in tissue degradation. Oral Dis 1996: 2(1): 70–76. 90 Riley C, London JP, Burmeister JA. Periodontal health in 200 HIV-positive patients. J Oral Pathol Med 1992: 21: 124–127. 91 Roberts FA, McCaffery KA, Michalek SM. Profile of cytokine mRNA expression in chronic adult periodontitis. J Dent Res 1997: 76: 1833–1839. 92 Romagnani S. T-cell subsets (Th1 versus Th2). Ann Allergy Asthma Immunol 2000: 85, 9–18; quiz 18, 21. 93 Rostock MH, Fry HR, Turner JE. Severe gingival overgrowth associated with cyclosporine therapy. J Periodontol 1986: 57: 294–299. 94 Safkan B, Knuuttila M. Corticosteroid therapy and periodontal disease. J Clin Periodontol 1984: 11: 515–522. 95 Salvi GE, Lawrence HP, Offenbacher S, Beck JD. Influence of risk factors on the pathogenesis of periodontitis. Periodontol 2000 1997: 14: 173–201. 96 SanGiacomo TR, Tan PM, Loggi DG, Itkin AB. Progressive osseous destruction as a complication of HIV-periodontitis. Oral Surg Oral Med Oral Pathol 1990: 70: 476–479. 97 Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, Young M, Robey PG, Wang CY, Shi S. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004: 364: 149–155. 98 Seymour GJ, Greenspan JS. The phenotypic characterization of lymphocyte subpopulations in established human periodontal disease. J Periodontal Res 1979: 14: 39–46. 99 Seymour GJ, Cole KL, Powell RN, Lewins E, Cripps AW, Clancy RL. Interleukin-2 production and bone-resorption activity in vitro by unstimulated lymphocytes extracted from chronically-inflamed human periodontal tissues. Arch Oral Biol 1985: 30: 481–484. 100 Seymour RA, Smith DG, Rogers SR. The comparative effects of azathioprine and cyclosporin on some gingival health parameters of renal transplant patients. A longitudinal study. J Clin Periodontol 1987: 14: 610–613. 101 Shapira L, Soskolne WA, Sela MN, Offenbacher S, Barak V. The secretion of PGE2, IL-1 beta, IL-6, and TNF alpha by adherent mononuclear cells from early onset periodontitis patients. J Periodontol 1994: 65: 139–146. 102 Shapira L, Houri-Haddad Y, Frolov I, Halabi A, Ben-Nathan D. The effect of stress on the inflammatory response to Porphyromonas gingivalis in a mouse subcutaneous chamber model. J Periodontol 1999: 70: 289–293. 103 Sigusch B, Klinger G, Glockmann E, Simon HU. Early-onset and adult periodontitis associated with abnormal cytokine production by activated T lymphocytes. J Periodontol 1998: 69: 1098–1104. 104 Socransky SS, Haffajee AD. The bacterial etiology of destructive periodontal disease: current concepts. J Periodontol 1992: 63: 322–331. 105 Stepnick RJ, Nakata TM, Zipkin I. The effects of age and fluoride exposure on fluoride, citrate and carbonate content of human cementum. J Periodontol 1975: 46: 45–50. 106 Sugawara M, Yamashita K, Yoshie H, Hara K. Detection of, and anti-collagen antibody produced by, CD5-positive B cells in inflamed gingival tissues. J Periodontal Res 1992: 27: 489–498. 107 Sutcliffe P. A longitudinal study of gingivitis and puberty. J Periodontal Res 1972: 7: 52–58. 108 Takahashi K, Mooney J, Frandsen EV, Kinane DF. IgG and IgA subclass mRNA-bearing plasma cells in periodontitis gingival tissue and immunoglobulin levels in the gingival crevicular fluid. Clin Exp Immunol 1997: 107: 158–165. 109 Thomason JM, Seymour RA, Ellis JS, Kelly PJ, Parry G, Dark J, Idle JR. Iatrogenic gingival overgrowth in cardiac transplantation. J Periodontol 1995: 66: 742–746. 110 Thorstensson H. Periodontal disease in adult insulin-dependent diabetics. Swed Dent J Suppl 1995: 107: 1–68. 111 Trombelli L, Tatakis DN, Scapoli C, Bottega S, Orlandini E, Tosi M. Modulation of clinical expression of plaque-induced gingivitis. II. Identification of ''high-responder'' and ''low-responder'' subjects. J Clin Periodontol 2004: 31: 239–252. 112 Van der Weijden GA, Timmerman MF, Danser MM, Nijboer A, Saxton CA, Van der Velden U. Effect of pre-experimental maintenance care duration on the development of gingivitis in a partial mouth experimental gingivitis model. J Periodontal Res 1994: 29: 168–173. 113 Vittek J, Rappaport SC, Gordon GG, Munnangi PR, Southren AL. Concentration of circulating hormones and metabolism of androgens by human gingiva. J Periodontol 1979: 50: 254–264. 114 Weidmann W, Lahrsow J, Naujokd R. The effect of periodontal resistance on experimental gingivitis. Dtsch Zahnartztl 1979: 34: 6–9. 115 Winkler JR, Murray PA, Grassi M, Hammerle C. Diagnosis and management of HIV-associated periodontal lesions. J Am Dent Assoc Suppl 1989: Nov: 25S–34S. 116 Yamazaki K, Nakajima T, Aoyagi T, Hara K. Immunohistological analysis of memory T lymphocytes and activated B lymphocytes in tissues with periodontal disease. J Periodontal Res 1993: 28: 324–334. 117 Yamazaki K, Nakajima T, Hara K. Immunohistological analysis of T cell functional subsets in chronic inflammatory periodontal disease. Clin Exp Immunol 1995: 99: 384–391. 118 Yamazaki K, Nakajima T, Kubota Y, Gemmell E, Seymour GJ, Hara K. Cytokine messenger RNA expression in chronic inflammatory periodontal disease. Oral Microbiol Immunol 1997: 12: 281–287. Citing Literature Volume43, Issue1February 2007Pages 278-293 ReferencesRelatedInformation