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Clinical and In Vitro Evaluation of Cidofovir for Treatment of Adenovirus Infection in Pediatric Hematopoietic Stem Cell Transplant Recipients

2005; Oxford University Press; Volume: 41; Issue: 12 Linguagem: Inglês

10.1086/498151

1537-6591

William J. Muller, Myron J. Levin, Young Kyoo Shin, Christine C. Robinson, Ralph Quinones, J. Malcolm, E. Hild, Dexiang Gao, Roger Giller,

Parvovirus B19 Infection Studies

Post-hematopoietic stem cell transplantation (HSCT) adenovirus infections were identified in 31 of 204 consecutive pediatric HSCT patients, 18 of whom had severe manifestations of infection. Cidofovir treatment led to clinical improvement in 8 of 10 patients with severe infection and to virologic clearance in 9 patients. In vitro susceptibility to cidofovir was demonstrated in 12 clinical adenovirus isolates. Cidofovir is a promising treatment option for this population.