The “Complex‐in‐a‐Complex” Cations [(acac) 2 M⊂Ru 6 ( p ‐ i PrC 6 H 4 Me) 6 (tpt) 2 (dhbq) 3 ] 6+ : A Trojan Horse for Cancer Cells
2008; Wiley; Volume: 47; Issue: 20 Linguagem: Inglês
10.1002/anie.200800186
ISSN1521-3773
AutoresBruno Therrien, Georg Süß‐Fink, P. Govindaswamy, Anna K. Renfrew, Paul J. Dyson,
Tópico(s)Supramolecular Chemistry and Complexes
ResumoAngewandte Chemie International EditionVolume 47, Issue 20 p. 3773-3776 Communication The “Complex-in-a-Complex” Cations [(acac)2M⊂Ru6(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+: A Trojan Horse for Cancer Cells† Bruno Therrien Dr., Bruno Therrien Dr. [email protected] Institut de Chimie, Université de Neuchâtel, Case postale 158, 2009 Neuchâtel, Switzerland, Fax: (+41) 32-718-2511 http://www2.unine.ch/chs/page9676.htmlSearch for more papers by this authorGeorg Süss-Fink Prof. Dr., Georg Süss-Fink Prof. Dr. Institut de Chimie, Université de Neuchâtel, Case postale 158, 2009 Neuchâtel, Switzerland, Fax: (+41) 32-718-2511 http://www2.unine.ch/chs/page9676.htmlSearch for more papers by this authorPadavattan Govindaswamy Dr., Padavattan Govindaswamy Dr. Institut de Chimie, Université de Neuchâtel, Case postale 158, 2009 Neuchâtel, Switzerland, Fax: (+41) 32-718-2511 http://www2.unine.ch/chs/page9676.htmlSearch for more papers by this authorAnna K. Renfrew, Anna K. Renfrew Institut des Sciences et Ingénierie Chimique, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, SwitzerlandSearch for more papers by this authorPaul J. Dyson Prof. Dr., Paul J. Dyson Prof. Dr. Institut des Sciences et Ingénierie Chimique, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, SwitzerlandSearch for more papers by this author Bruno Therrien Dr., Bruno Therrien Dr. [email protected] Institut de Chimie, Université de Neuchâtel, Case postale 158, 2009 Neuchâtel, Switzerland, Fax: (+41) 32-718-2511 http://www2.unine.ch/chs/page9676.htmlSearch for more papers by this authorGeorg Süss-Fink Prof. Dr., Georg Süss-Fink Prof. Dr. Institut de Chimie, Université de Neuchâtel, Case postale 158, 2009 Neuchâtel, Switzerland, Fax: (+41) 32-718-2511 http://www2.unine.ch/chs/page9676.htmlSearch for more papers by this authorPadavattan Govindaswamy Dr., Padavattan Govindaswamy Dr. Institut de Chimie, Université de Neuchâtel, Case postale 158, 2009 Neuchâtel, Switzerland, Fax: (+41) 32-718-2511 http://www2.unine.ch/chs/page9676.htmlSearch for more papers by this authorAnna K. Renfrew, Anna K. Renfrew Institut des Sciences et Ingénierie Chimique, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, SwitzerlandSearch for more papers by this authorPaul J. Dyson Prof. Dr., Paul J. Dyson Prof. Dr. Institut des Sciences et Ingénierie Chimique, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, SwitzerlandSearch for more papers by this author First published: 28 April 2008 https://doi.org/10.1002/anie.200800186Citations: 393 † This work was supported by the Fonds National Suisse de la Recherche Scientifique. A generous loan of ruthenium trichloride hydrate from Johnson Matthey Technology Centre is gratefully acknowledged. M=Pd, Pt; acac=acetylacetonato; tpt=2,4,6-tris(pyridin-4-yl)-1,3,5-triazine; dhbq=2,5-dihydroxy-1,4-benzoquinonato. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract The start of an odyssey? The cytotoxicities of the large cationic arene–ruthenium prismatic cage 16+, and its “complex-in-a-complex” derivatives [(acac)2M⊂1]6+ (M=Pd, Pt; acac=acetylacetonate; see picture), are evaluated in comparison with free [M(acac)2]. The differences in cytotoxicity suggest that, like a “Trojan Horse”, leaching of the guest from the cage once inside a cell accelerates and increases the cytotoxic effect. Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z800186_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1 1aD. Fiedler, R. G. Bergman, K. N. Raymond, Angew. Chem. 2006, 118, 759–762; Angew. Chem. Int. Ed. 2006, 45, 745–748; 1bK. Severin, Chem. Commun. 2006, 3859–3867. 2 2aC. J. Kuehl, T. Yamamoto, S. R. Seidel, P. J. Stang, Org. Lett. 2002, 4, 913–915; 2bC. J. Kuehl, Y. K. Kryschenko, U. Radhakrishnan, S. R. Seidel, S. D. Huang, P. J. Stang, Proc. Natl. Acad. Sci. USA 2002, 99, 4932–4936; 2cH.-B. Yang, K. Ghosh, B. H. Northrop, P. J. Stang, Org. Lett. 2007, 9, 1561–1564. 3 3aK. Kumazawa, K. Biradha, T. Kusukawa, T. Okano, M. Fujita, Angew. 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Perkin Trans. 1 1995, 2231–2246. Citing Literature Volume47, Issue20May 5, 2008Pages 3773-3776 ReferencesRelatedInformation
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