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Cutting Edge: Tyk2 Is Required for the Induction and Nuclear Translocation of Daxx Which Regulates IFN-α-Induced Suppression of B Lymphocyte Formation

2002; American Association of Immunologists; Volume: 169; Issue: 9 Linguagem: Inglês

10.4049/jimmunol.169.9.4707

1550-6606

Kazuya Shimoda, Kenjirou Kamesaki, Akihiko Numata, Kenichi Aoki, Tadashi Matsuda, Kenji Oritani, Sadafumi Tamiya, Kouji Kato, Ken Takase, Rie Imamura, Tetsuya Yamamoto, Toshihiro Miyamoto, Koji Nagafuji, Hisashi Gondo, Seiho Nagafuchi, Kei-ichi Nakayama, Mine Harada,

Cytokine Signaling Pathways and Interactions

Abstract IFN-α inhibits B lymphocyte development, and the nuclear protein Daxx has been reported to be essential for this biological activity. We show in this study that IFN-α inhibits the clonal proliferation of B lymphocyte progenitors in response to IL-7 in wild-type, but not in tyk2-deficient, mice. In addition, the IFN-α-induced up-regulation and nuclear translocation of Daxx are completely abrogated in the absence of tyk2. Therefore, tyk2 is directly involved in IFN-α signaling for the induction and translocation of Daxx, which may result in B lymphocyte growth arrest and/or apoptosis.