H 2 S Induces a Suspended Animation-Like State in Mice
2005; American Association for the Advancement of Science; Volume: 308; Issue: 5721 Linguagem: Inglês
10.1126/science.1108581
ISSN1095-9203
AutoresEric Blackstone, Mike Morrison, Mark B. Roth,
Tópico(s)Adipose Tissue and Metabolism
ResumoMammals normally maintain their core body temperature (CBT) despite changes in environmental temperature. Exceptions to this norm include suspended animation-like states such as hibernation, torpor, and estivation. These states are all characterized by marked decreases in metabolic rate, followed by a loss of homeothermic control in which the animal's CBT approaches that of the environment. We report that hydrogen sulfide can induce a suspended animation-like state in a nonhibernating species, the house mouse (Mus musculus). This state is readily reversible and does not appear to harm the animal. This suggests the possibility of inducing suspended animation-like states for medical applications.
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