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Introducing MINA – The Molecularly Imprinted Nanoparticle Assay

2014; Wiley; Volume: 10; Issue: 6 Linguagem: Inglês

10.1002/smll.201301996

1613-6829

Roman V. Shutov, António Guerreiro, Ewa Moczko, Isabel Perez de Vargas‐Sansalvador, Iva Chianella, Michael J. Whitcombe, Sergey A. Piletsky,

Biosensors and Analytical Detection

A new ELISA- (enzyme-linked immunosorbent assay)-like assay is demonstrated in which no elements of biological origin are used for molecular recognition or signaling. Composite imprinted nanoparticles that contain a catalytic core and which are synthesized by using a solid-phase approach can simultaneously act as recognition/signaling elements, and be used with minimal modifications to standard assay protocols. This assay provides a new route towards replacement of unstable biomolecules in immunoassays. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.