Causes of Failure in Prevention of Vertical Infection by Hepatitis B Virus
1986; Wiley; Volume: 28; Issue: 3 Linguagem: Inglês
10.1111/j.1442-200x.1986.tb00730.x
ISSN1442-200X
AutoresKazuo Shiraki, K Tanimoto, Kazuhito Yamada, Takayoshi Okada,
Tópico(s)Vaccine Coverage and Hesitancy
ResumoAbstract In order to prevent the hepatitis B virus carrier state, 190 infants born to hepatitis‐Be antigen positive hepatitis‐B surface antigen carrier mothers were treated with hepatitis‐B hyperimmune globulin(HBIG) and hepatitis‐B vaccine after birth; however, 8 infants(4.2%) ultimately became carriers. There were three different causes for the failure, namely 1) prenatal infection, 2) insufficiency of HBIG to neutralize the virus transmitted, and 3) poor responsiveness of the infant to the vaccine. The present study suggests that early vaccination in the neonatal period increases the rate of poor responders as compared to later vaccination.
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