Revisão Acesso aberto Revisado por pares

Gene Therapy for Infectious Diseases

1998; American Society for Microbiology; Volume: 11; Issue: 1 Linguagem: Inglês

10.1128/cmr.11.1.42

ISSN

1098-6618

Autores

Bruce A. Bunnell, Richard A. Morgan,

Tópico(s)

Viral gastroenteritis research and epidemiology

Resumo

Gene therapy is being investigated as an alternative treatment for a wide range of infectious diseases that are not amenable to standard clinical management. Approaches to gene therapy for infectious diseases can be divided into three broad categories: (i) gene therapies based on nucleic acid moieties, including antisense DNA or RNA, RNA decoys, and catalytic RNA moieties (ribozymes); (ii) protein approaches such as transdominant negative proteins and single-chain antibodies; and (iii) immunotherapeutic approaches involving genetic vaccines or pathogen-specific lymphocytes. It is further possible that combinations of the aforementioned approaches will be used simultaneously to inhibit multiple stages of the life cycle of the infectious agent.

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