FURTHER INVESTIGATIONS OF LUPUS ANTICOAGULANT INTERFERENCE IN A FUNCTIONAL ASSAY FOR TISSUE FACTOR PATHWAY INHIBITOR
1997; Elsevier BV; Volume: 87; Issue: 2 Linguagem: Inglês
10.1016/s0049-3848(97)00124-2
ISSN1879-2472
Autores Tópico(s)Venous Thromboembolism Diagnosis and Management
ResumoTissue factor pathway inhibitor (TFPI) is a natural inhibitor that regulates the initiation of coagulation by inhibiting tissue factor - activated factor VII (TF - FVIIa) in the presence of activated factor X (FXa) [ 1 BROZE G.J. WARREN L.A. NOVOTNY W.F. HIGUCHI D.A. GIRARD J.J. MILETICH J.P. The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action. Blood. 1988; 71: 335-343 Crossref PubMed Google Scholar ]. Although the precise role of TFPI in haemostasis is yet to be determined, it's ability to inhibit TF - FVIIa in the presence of FXa suggests that is does have an important physiological significance.
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